BDBM9063 5,6-Dimethoxy-2-{[7-(1,2,3,4-tetrahydro-acridin-9-ylamino)-heptylamino]-methyl}-indan-1-one::5,6-dimethoxy-2-({[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]amino}methyl)-2,3-dihydro-1H-inden-1-one::CHEMBL484306::Donepezil-tacrine hybrid 8
SMILES COc1cc2CC(CNCCCCCCCNc3c4CCCCc4nc4ccccc34)C(=O)c2cc1OC
InChI Key InChIKey=LSAKEKKNQBBHNE-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 9063
Affinity DataIC50: 25nMpH: 8.0 T: 30°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
TargetCholinesterase(Human)
Laboratori De Qu�Mica Farmac�Utica (Unitat Associada Al Csic)
Curated by ChEMBL
Laboratori De Qu�Mica Farmac�Utica (Unitat Associada Al Csic)
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human serum BChE by Ellman's assayMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of bovine erythrocyte AChE by Ellman's assayMore data for this Ligand-Target Pair
TargetCholinesterase(Human)
Laboratori De Qu�Mica Farmac�Utica (Unitat Associada Al Csic)
Curated by ChEMBL
Laboratori De Qu�Mica Farmac�Utica (Unitat Associada Al Csic)
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair