BDBM912 (3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-methyl-4-[(2S)-3-methyl-2-[(2S)-3-methyl-2-(3-methylbutanamido)butanamido]butanamido]heptanamido]propanamido]-6-methylheptanoic acid::CHEMBL296588::Iva-Val-Val-Sta-Ala-Sta-OH::N-[(3-Methyl-1-oxobutyl)-L-valyl-L-valyl-4-amino-3-hydroxy-6-methylheptanoyl-L-alanyl]-4-amino-3-hydroxy-6-methylheptanoic acid::PEPSTATIN::Pepstatine::US9115083, Pepstatin
SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CC(C)C)C(C)C)C(C)C)[C@@H](O)CC(O)=O
InChI Key InChIKey=FAXGPCHRFPCXOO-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 93 hits for monomerid = 912
Affinity DataKd: 0.00371nMAssay Description:Binding affinity against Cathepsin DMore data for this Ligand-Target Pair
Affinity DataKi: 0.0100nMAssay Description:Binding affinity against human cathepsin DMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human cathepsin D using GKPILFFRLK(DNP)-D-RNH2) labeled MCA as substrate preincubated for 10 mins followed by substrate addition measur...More data for this Ligand-Target Pair
Affinity DataKi: 0.0560nMAssay Description:Inhibition of porcine pepsinMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of human recombinant cathepsin E using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate preincubated for 15 mins f...More data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of secreted cathepsin D in human MDA-MB-231 cells using Mca-Gly-Lys-Pro-Ile-Leu-PhePhe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate pretreated...More data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of secreted cathepsin E in human MDA-MB-231 cells using Mca-Gly-Lys-Pro-Ile-Leu-PhePhe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate pretreated...More data for this Ligand-Target Pair
Affinity DataIC50: 0.173nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
Affinity DataIC50: 0.181nMAssay Description:Inhibition of cathepsin EMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant human C-terminal His10-tagged cathepsin E (Gln18 to Pro396 residues) using Mca-Gly-Lys-Pro-Ile-Leu-PhePhe-Arg-Leu-Lys-(Dnp)...More data for this Ligand-Target Pair
TargetPlasmepsin IV [1-448](malaria parasite P. falciparum)
Latvian Institute of Organic Synthesis
Curated by ChEMBL
Latvian Institute of Organic Synthesis
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 4 using DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS as substrate preincubated for 30 mins followed by...More data for this Ligand-Target Pair
Affinity DataIC50: 0.350nMAssay Description:Inhibition of human liver cathepsin D using Mca-Gly-Lys-Pro-Ile-Leu-PhePhe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate pretreated for 15 mins followed b...More data for this Ligand-Target Pair
Affinity DataIC50: 0.350nMAssay Description:Inhibition of human liver cathepsin D using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate preincubated for 15 mins followe...More data for this Ligand-Target Pair
Affinity DataIC50: 0.420nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin-2 using DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS as substrate preincubated for 30 mins followed by...More data for this Ligand-Target Pair
Affinity DataIC50: 0.446nMAssay Description:Inhibition of Cathepsin E (unknown origin) using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate incubated for 120 mins by f...More data for this Ligand-Target Pair
Affinity DataIC50: 0.446nMAssay Description:Inhibition of cathepsin E by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.490nMAssay Description:Inhibition of human placenta CatD using Abz-Lys-Pro-Ala-Glu-Phe-Nph-Ala-Leu as substrate preincubated for 10 mins followed by substrate addition and ...More data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibition of cathepsin D.More data for this Ligand-Target Pair
Affinity DataIC50: 0.550nMAssay Description:Inhibition of human cathepsin D by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.680nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin-2 by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.693nMAssay Description:Inhibition of recombinant human liver Cathepsin D using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate incubated for 120 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 0.693nMAssay Description:Inhibition of cathepsin D by fluorescence assayMore data for this Ligand-Target Pair
TargetPlasmepsin I(malaria parasite P. falciparum)
Latvian Institute of Organic Synthesis
Curated by ChEMBL
Latvian Institute of Organic Synthesis
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin-1 using DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS as substrate preincubated for 30 mins followed by...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of Cathepsin D (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of cathepsin D (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.46nMAssay Description:Inhibition of recombinant HIV1 proteaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against human liver Cathepsin D using Cathepsin D assay.More data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
Affinity DataIC50: 2.33nMAssay Description:Inhibition of cathepsin D (unknown origin) using hemoglobin as substrate after 30 min by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of cathepsin D in human MCF7 cells by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of cathepsin E in human MCF7 cells by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Compound was measured for the inhibition of pepsin hydrolysis of hemoglobin.More data for this Ligand-Target Pair
Affinity DataIC50: 7.5nMAssay Description:Inhibition of cathepsin E (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Tested for inhibition of Cathepsin D from bovineMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMpH: 2.0Assay Description:Inhibitory activity was evaluated against pepsin using porcine pepsin (sigma), porcine hemoglobin (sigma) and 0.02 M KCl-HCl buffer (pH 2)More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Compound was tested for inhibition of porcine pepsinMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of porcine pepsinMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Binding affinity to HIV-1 proteaseMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Tested for inhibition of pepsin from porcineMore data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibitory activity was evaluated against bovine cathepsin D (sigma)More data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Compound was tested for inhibition of bovine cathepsin DMore data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibition of bovine cathepsin DMore data for this Ligand-Target Pair
Affinity DataKi: 36nMAssay Description:Inhibition of HIV-1 recombinant protease using DABCYL-GABA-Ser-Asn-Tyr-Pro-Ile-Val-Gln-EDANS as substrate incubated for 30 mins prior to substrate ad...More data for this Ligand-Target Pair
Affinity DataKi: 38nMAssay Description:Inhibition of HIV1 protease by Lineweaver-Burke methodMore data for this Ligand-Target Pair
Affinity DataKi: 38nMAssay Description:Inhibition of HIV1 protease by Hanes methodMore data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of HIV1 protease by FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 50nMAssay Description:Inhibition of HIV1 protease by Dixon methodMore data for this Ligand-Target Pair
Affinity DataKi: 51nMAssay Description:Inhibition of HIV-1 recombinant protease using DABCYL-GABA-Ser-Asn-Tyr-Pro-Ile-Val-Gln-EDANS as substrate incubated for 30 mins prior to substrate ad...More data for this Ligand-Target Pair
Affinity DataKi: 52nMAssay Description:Inhibition of HIV-1 recombinant protease using DABCYL-GABA-Ser-Asn-Tyr-Pro-Ile-Val-Gln-EDANS as substrate incubated for 30 mins prior to substrate ad...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 9(Human)
University of Florida
Curated by ChEMBL
University of Florida
Curated by ChEMBL
Affinity DataIC50: 56nMAssay Description:Inhibition of ADAM9 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
