BDBM92843 Bisanilinopyrimidine, 12a::US9249124, 59

SMILES Clc1ccccc1Nc1ccnc(Nc2ccc(cc2)-c2nnn[nH]2)n1

InChI Key InChIKey=GADYBZMYJCZJLX-UHFFFAOYSA-N

Data  6 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 92843   

TargetAurora kinase A(Human)
Moffitt Cancer Center

LigandPNGBDBM92843(Bisanilinopyrimidine, 12a | US9249124, 59)
Affinity DataIC50:  3.10nMAssay Description:In vitro enzyme activity assay using Aurora Kinase A. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetAurora kinase B(Human)
Moffitt Cancer Center

LigandPNGBDBM92843(Bisanilinopyrimidine, 12a | US9249124, 59)
Affinity DataIC50:  226nMAssay Description:In vitro enzyme activity assay using Aurora Kinase A. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Human)
Moffitt Cancer Center

LigandPNGBDBM92843(Bisanilinopyrimidine, 12a | US9249124, 59)
Affinity DataIC50:  3.10nM Kd:  18nMpH: 7.4Assay Description:The binding of inhibitors to Aurora A kinase was analyzed with a MicroCal iTC200 titration calorimeter (GE Healthcare, Piscataway, N.J.). The protein...More data for this Ligand-Target Pair
In DepthDetails US Patent
PDB3D3D Structure (crystal)

TargetAurora kinase A(Human)
Moffitt Cancer Center

LigandPNGBDBM92843(Bisanilinopyrimidine, 12a | US9249124, 59)
Affinity DataIC50: >1.00E+4nMT: 37°CAssay Description:Specifically, MDA-MB-468 cells (American Type Culture Collection) were maintained in Dulbecco's modified Eagle's medium (DMEM) plus 10% fetus bovine ...More data for this Ligand-Target Pair
In DepthDetails US Patent
PDB3D3D Structure (crystal)

TargetAurora kinase A(Human)
Moffitt Cancer Center

LigandPNGBDBM92843(Bisanilinopyrimidine, 12a | US9249124, 59)
Affinity DataIC50:  3.10nMpH: 7.4 T: 18°CAssay Description:Aurora A was exchanged into 50 mM phosphate buffer (pH 7.4) including 1 mM DTT via PD-10 columns and was concentrated to 20 mg mL-1 using Amicon Ultr...More data for this Ligand-Target Pair
In DepthDetails US Patent
PDB3D3D Structure (crystal)

TargetAurora kinase A(Human)
Moffitt Cancer Center

LigandPNGBDBM92843(Bisanilinopyrimidine, 12a | US9249124, 59)
Affinity DataIC50:  3.10nMpH: 7.4 T: 25°CAssay Description:Reactions were carried out at room temperature in 15 mM HEPES buffer (pH 7.4) containing 20 mM NaCl, 1 mM EGTA, 0.02% Tween 20, 10 mM MgCl2, 5% (v/v)...More data for this Ligand-Target Pair
In DepthDetails US Patent
PDB3D3D Structure (crystal)