BDBM50203126 3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrido[2,1-a]isoquinolin-5-ylium::9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ylium::9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ylium chloride::9,10-dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ylium; chloride::BERBERINE::Berberinechloride::CHEMBL12089::berberine dimer::cid_12456
SMILES COc1ccc2cc3-c4cc5OCOc5cc4CC[n+]3cc2c1OC
InChI Key InChIKey=YBHILYKTIRIUTE-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 82 hits for monomerid = 50203126
TargetSortase family protein(Staphylococcus aureus)
Indian Institute of Technology Delhi
Curated by ChEMBL
Indian Institute of Technology Delhi
Curated by ChEMBL
Affinity DataIC50: 8.70nMAssay Description:Inhibition of recombinant Staphylococcus aureus SrtA using DabcylQALPETGEE-Edans as substrate by FRET assayMore data for this Ligand-Target Pair
TargetSortase family protein(Staphylococcus aureus)
Indian Institute of Technology Delhi
Curated by ChEMBL
Indian Institute of Technology Delhi
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant Staphylococcus aureus SrtA using DabcylQALPETGEE-Edans as substrate by FRET assayMore data for this Ligand-Target Pair
TargetCell division protein FtsZ(Escherichia coli (strain K12))
University of Wisconsin-Madison
Curated by ChEMBL
University of Wisconsin-Madison
Curated by ChEMBL
Affinity DataKd: 23nMAssay Description:Displacement of bis-ANS from Escherichia coli FtsZMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of TDO (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of AChE assessed as hydrolysis of acetylcholine preincubated for 15 mins measured after 15 mins by colorimetric Ellman assayMore data for this Ligand-Target Pair
Affinity DataKi: 44nMAssay Description:Inhibition of human CYP1B1 expressed in Escherichia coli DH5alpha coexpressing human NADPH-P450 reductase using 4-estradiol as substrate in presence ...More data for this Ligand-Target Pair
Affinity DataIC50: 94nMAssay Description:Inhibition of human CYP1B1 expressed in Escherichia coli DH5alpha cell membranes coexpressing human NADPH-cytochrome P450 reductase using 7-Ethoxyres...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine as substrate assessed as substrate hydrolysis by spectrophotometric/Ellman methodMore data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 289nMAssay Description:Inhibition of electric eel AChE by enzyme kinetics assayMore data for this Ligand-Target Pair
Affinity DataIC50: 330nMAssay Description:Inhibition of human CYP1B1 expressed in Escherichia coli DH5alpha coexpressing human NADPH-P450 reductase using 4-estradiol as substrate in presence ...More data for this Ligand-Target Pair
Affinity DataIC50: 374nMAssay Description:Inhibition of electric eel AChE by modified Ellman methodMore data for this Ligand-Target Pair
Affinity DataIC50: 374nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins prior to substrate addition by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 374nMAssay Description:Inhibition of electric eel AChE after 15 mins by Ellman's method using acetylcholine as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 374nMAssay Description:Inhibition of electric eel AChE using acetylcholine chloride as substrate preincubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 374nMAssay Description:Inhibition of electric eel AChE by Ellman's assayMore data for this Ligand-Target Pair
Affinity DataIC50: 374nMAssay Description:Inhibition of electric eel AcetylcholinesteraseMore data for this Ligand-Target Pair
Affinity DataIC50: 374nMAssay Description:Inhibition of electric eel AChE using acetylcholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 374nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine chloride substrate as substrate preincubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Human)
University Clinic Hospital of Valencia
Curated by ChEMBL
University Clinic Hospital of Valencia
Curated by ChEMBL
Affinity DataEC50: 580nMAssay Description:Agonist activity at PPARalpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 610nMAssay Description:Inhibition of human AChE by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Human)
University Clinic Hospital of Valencia
Curated by ChEMBL
University Clinic Hospital of Valencia
Curated by ChEMBL
Affinity DataKi: 730nMAssay Description:Binding affinity to PPARalpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 770nMpH: 8.0 T: 2°CAssay Description:Briefly, 140 μL of sodium phosphate buffer (pH 8.0), 20 μL of each tested compound with different concentrations (4, 20, and 100 μM) a...More data for this Ligand-Target Pair
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of BChE (unknown origin) using butyrylthiocholine as substrate assessed as substrate hydrolysis by spectrophotometric/Ellman methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+3nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 15 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of CYP1B1 in human HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.74E+3nMAssay Description:Inhibition of electric eel AChE by Ellman's methodMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Shanghai Institute of Materia Medica
Curated by ChEMBL
Shanghai Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.08E+3nMAssay Description:Inhibition of N-terminal His-tagged human AKR1C3 (1 to 323 residues) expressed in Escherichia coli using 4-adione as substrate in presence of NADPH b...More data for this Ligand-Target Pair
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of purified recombinant human NEK7 incubated for 15 mins before ATP and substrate addition and further incubated for 40 mins by ADPGlo kin...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Human)
Beijing University of Chinese Medicine
Curated by ChEMBL
Beijing University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 6.97E+3nMAssay Description:Inhibition of recombinant LSD1 (unknown origin) expressed in Escherichia coli BL21 using H3K4me2 as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
TargetSentrin-specific protease 8(Human)
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
TargetSentrin-specific protease 8(Human)
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Affinity DataIC50: 8.91E+3nMAssay Description:Inhibition of p300 HAT (unknown origin) using 3H-acetyl-CoA as substrate assessed as H3 peptide acetylation preincubated with compound for 15 mins fo...More data for this Ligand-Target Pair
Affinity DataKi: 9.20E+3nMAssay Description:Inhibition of horse serum BChE by enzyme kinetics assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.40E+3nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine chloride as substrate incubated for 15 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Staphylococcus aureus recombinant FTsZ preincubated for 10 mins followed by compound addition measured after 30 mins by Cytophos phosph...More data for this Ligand-Target Pair
TargetCell division protein FtsZ(Escherichia coli (strain K12))
University of Wisconsin-Madison
Curated by ChEMBL
University of Wisconsin-Madison
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant Escherichia coli K12 FtsZ assembly by light-scattering assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of AMPK signalling pathway in human HepG2 cellsMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Human)
University Clinic Hospital of Valencia
Curated by ChEMBL
University Clinic Hospital of Valencia
Curated by ChEMBL
Affinity DataEC50: 1.40E+4nMAssay Description:Agonist activity at PPARdelta (unknown origin)More data for this Ligand-Target Pair
TargetNeuraminidase(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Konkuk University
Curated by ChEMBL
Konkuk University
Curated by ChEMBL
Affinity DataKi: 1.43E+4nMAssay Description:Inhibition of neuraminidase in influenza A virus (A/Puerto Rico/8/1934(H1N1)) pre-incubated for 30 mins before NA-Star substrate addition for 30 mins...More data for this Ligand-Target Pair
Affinity DataKd: 1.56E+4nMAssay Description:Binding affinity to purified recombinant human NEK7 by SPR analysisMore data for this Ligand-Target Pair
TargetCell division protein FtsZ(Escherichia coli (strain K12))
University of Wisconsin-Madison
Curated by ChEMBL
University of Wisconsin-Madison
Curated by ChEMBL
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of recombinant Escherichia coli K12 FtsZ GTPase activity by malachite green sodium molybdate assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.74E+4nMAssay Description:Inhibition of recombinant human acetylcholinesterase using acetylthiocholine iodide as substrate preincubated with enzyme for 5 mins followed by subs...More data for this Ligand-Target Pair
Affinity DataIC50: 1.82E+4nMAssay Description:Inhibition of horse serum BChE by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.82E+4nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine chloride as substrate preincubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.82E+4nMAssay Description:Inhibition of equine serum BuChE using butyrylcholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.82E+4nMAssay Description:Inhibition of equine serum BuChE by Ellman's methodMore data for this Ligand-Target Pair
