BDBM50636456 Sonrotoclax::Bgb 11417::Bgb-11417::BGB-11417::BGB11417

SMILES CC(C)c1ccccc1[C@@H]1CCCN1C1CC2(CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(NC[C@H]5CC[C@](C)(O)CC5)c([N+](=O)[O-])c4)c(Oc4cnc5[nH]ccc5c4)c3)CC2)C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50636456   

TargetApoptosis regulator Bcl-2(Human)
BeiGene(Beiing) Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50636456(Sonrotoclax | Bgb 11417 | Bgb-11417 | BGB-11417 | ...)
Affinity DataIC50: 0.0190nMAssay Description:Inhibition of Bcl-2 (unknown origin) using (Ac-GQVGRQLAIIGDK (FITC) INR-amide) as substrate preincubated for 30 mins followed by substrate addition a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
BeiGene(Beiing) Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50636456(Sonrotoclax | Bgb 11417 | Bgb-11417 | BGB-11417 | ...)
Affinity DataKd:  0.240nMAssay Description:Binding affinity to His-tagged Bcl-2 G101V mutant (unknown origin) by SPR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
BeiGene(Beiing) Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50636456(Sonrotoclax | Bgb 11417 | Bgb-11417 | BGB-11417 | ...)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of Bcl-2 G101V mutant (unknown origin) using (Ac-GQVGRQLAIIGDK (FITC) INR-amide) as substrate preincubated for 30 mins followed by substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetBcl-2-like protein 1(Human)
BeiGene(Beiing) Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50636456(Sonrotoclax | Bgb 11417 | Bgb-11417 | BGB-11417 | ...)
Affinity DataIC50: 28nMAssay Description:Inhibition of Bcl-Xl (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed