BDBM2691 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione::BIM-3::Bisindolyl deriv. 19

SMILES NCCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12

InChI Key InChIKey=APYXQTXFRIDSGE-UHFFFAOYSA-N

Data  13 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 2691   

TargetcAMP-dependent protein kinase catalytic subunit alpha(Bovine)
Laboratoires Glaxo

LigandBDBM2691(3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)Copy SMILESCopy InChI

Affinity DataIC50:  26nMAssay Description:The activity of PKC, activated by phosphatidylserine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich hi...More data for this Ligand-Target Pair

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TargetcAMP-dependent protein kinase catalytic subunit alpha(Rat)
Laboratoires Glaxo

LigandBDBM2691(3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)Copy SMILESCopy InChI

Affinity DataIC50:  500nMAssay Description:The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
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TargetPhosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform(Rabbit)
Laboratoires Glaxo

LigandBDBM2691(3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)Copy SMILESCopy InChI

Affinity DataIC50:  180nMAssay Description:The activity of PK is measured by its ability to transfer from [gamma-32P]ATP to phosphorylase b.More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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DrugBankMMDBPC cidPC sidPDBPatentsSimilars

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Target3-phosphoinositide-dependent protein kinase 1 [51-359](Human)
University of Dundee

LigandBDBM2691(3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)Copy SMILESCopy InChI

Affinity DataIC50:  4.00E+3nMpH: 7.5 T: 30°CAssay Description:In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankMMDBPC cidPC sidPDBPatentsSimilars

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Target3-phosphoinositide-dependent protein kinase 1 [51-359,V143T](Human)
University of Dundee

LigandBDBM2691(3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)Copy SMILESCopy InChI

Affinity DataIC50:  2.50E+3nMpH: 7.5 T: 30°CAssay Description:In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco...More data for this Ligand-Target Pair

Target InfoPDBMMDB
UniProtKB/SwissProt
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Ligand InfoPurchaseChEBI
DrugBankMMDBPC cidPC sidPDBPatentsSimilars

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Target3-phosphoinositide-dependent protein kinase 1 [51-359,L159M](Human)
University of Dundee

LigandBDBM2691(3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)Copy SMILESCopy InChI

Affinity DataIC50:  3.00E+3nMpH: 7.5 T: 30°CAssay Description:In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco...More data for this Ligand-Target Pair

Target InfoPDBMMDB
UniProtKB/SwissProt
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Ligand InfoPurchaseChEBI
DrugBankMMDBPC cidPC sidPDBPatentsSimilars

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TargetCalcium/calmodulin-dependent protein kinase type II subunit delta(Human)
Scios

Curated by ChEMBL

LigandBDBM2691(3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)Copy SMILESCopy InChI

Affinity DataIC50:  380nMAssay Description:Inhibition of CaMK2deltaMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

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Target3-phosphoinositide-dependent protein kinase 1 [51-359,E166D](Human)
University of Dundee

LigandBDBM2691(3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)Copy SMILESCopy InChI

Affinity DataIC50:  5.70E+3nMpH: 7.5 T: 30°CAssay Description:In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco...More data for this Ligand-Target Pair

Target InfoPDBMMDB
UniProtKB/SwissProt
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Ligand InfoPurchaseChEBI
DrugBankMMDBPC cidPC sidPDBPatentsSimilars

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Target3-phosphoinositide-dependent protein kinase 1 [51-359,T222A](Human)
University of Dundee

LigandBDBM2691(3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)Copy SMILESCopy InChI

Affinity DataIC50:  3.80E+3nMpH: 7.5 T: 30°CAssay Description:In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco...More data for this Ligand-Target Pair

Target InfoPDBMMDB
UniProtKB/SwissProt
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Ligand InfoPurchaseChEBI
DrugBankMMDBPC cidPC sidPDBPatentsSimilars

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Target3-phosphoinositide-dependent protein kinase 1 [51-359,V143T,T222A](Human)
University of Dundee

LigandBDBM2691(3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)Copy SMILESCopy InChI

Affinity DataIC50:  2.00E+3nMpH: 7.5 T: 30°CAssay Description:In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco...More data for this Ligand-Target Pair

Target InfoPDBMMDB
UniProtKB/SwissProt
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Ligand InfoPurchaseChEBI
DrugBankMMDBPC cidPC sidPDBPatentsSimilars

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TargetCalcium/calmodulin-dependent protein kinase type II subunit delta(Human)
Scios

Curated by ChEMBL

LigandBDBM2691(3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)Copy SMILESCopy InChI

Affinity DataIC50:  380nMAssay Description:Inhibition of CaMK2deltaMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseChEBI
DrugBankMMDBPC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMed
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TargetCalcium/calmodulin-dependent protein kinase type II subunit delta(Human)
Scios

Curated by ChEMBL

LigandBDBM2691(3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)Copy SMILESCopy InChI

Affinity DataIC50:  380nMAssay Description:Inhibition of CaMK2deltaMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseChEBI
DrugBankMMDBPC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMed
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Target3-phosphoinositide-dependent protein kinase 1 [51-359,A162V](Human)
University of Dundee

LigandBDBM2691(3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)Copy SMILESCopy InChI

Affinity DataIC50:  3.40E+3nMpH: 7.5 T: 30°CAssay Description:In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco...More data for this Ligand-Target Pair

Target InfoPDBMMDB
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPurchaseChEBI
DrugBankMMDBPC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedMMDB
PDB3D Structure (crystal)
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