BDBM50598686 BLU-945::BLU945::Blu-945

SMILES CO[C@@H]1CCN(C[C@@H]1F)c1nccc(Nc2cc3c(ccc(N4C[C@H](CS(C)(=O)=O)[C@H]4C)c3cn2)C(C)C)n1

InChI Key InChIKey=LIMFPAAAIVQRRD-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50598686   

TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598686(BLU-945 | Blu-945 | BLU945)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598686(BLU-945 | Blu-945 | BLU945)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of wild type EGFR L858R/T790M/C797S triple mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598686(BLU-945 | Blu-945 | BLU945)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR ex19del(746 to 750)/ T790M/C790S mutant (668 to end residues) expressed in baculovirus inf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598686(BLU-945 | Blu-945 | BLU945)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR ex19del(746 to 750)/T790M mutant (668 to end residues) expressed in baculovirus infected S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598686(BLU-945 | Blu-945 | BLU945)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598686(BLU-945 | Blu-945 | BLU945)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) expressed in mouse BaF3 cells assessed as inhibition of protein phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598686(BLU-945 | Blu-945 | BLU945)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R mutant (668 to end residues) expressed in baculovirus infected Sf9 insect cells expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598686(BLU-945 | Blu-945 | BLU945)
Affinity DataIC50: 25nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR ex19del (746 to 750) mutant expressed in baculovirus infected Sf9 insect cells expression ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598686(BLU-945 | Blu-945 | BLU945)
Affinity DataIC50: 40nMAssay Description:Inhibition of EGFR ex19del/T790M/C797S triple mutant (unknown origin) expressed in mouse BaF3 cells assessed as inhibition of protein phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598686(BLU-945 | Blu-945 | BLU945)
Affinity DataIC50: 130nMAssay Description:Inhibition of EGF-stimulated EGFR ex19del (746 to 750) mutant phosphorylation in human PC-9 cells preincubated for 4 to 5 hrs followed by EGF stimula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598686(BLU-945 | Blu-945 | BLU945)
Affinity DataIC50: 544nMAssay Description:Inhibition of wild type EGFR in human A-431 cells preincubated for 4 to 5 hrs followed by EGF stimulation for 10 mins by AlphaLISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598686(BLU-945 | Blu-945 | BLU945)
Affinity DataIC50: 683nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598686(BLU-945 | Blu-945 | BLU945)
Affinity DataIC50: 683nMAssay Description:Inhibition of N-terminal GST tagged recombinant wild type human EGFR expressed in baculovirus infected Sf9 insect cells expression system using 5-FAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed