BDBM50244035 Beta CCE::CHEMBL454606::cid_105078::ethyl 9H-pyrido[3,4-b]indole-3-carboxylate

SMILES CCOC(=O)c1cc2c(cn1)[nH]c1ccccc21

InChI Key InChIKey=KOVRZNUMIKACTB-UHFFFAOYSA-N

Data  16 KI  2 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50244035   

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
University Clinic For Psychiatry

Curated by PDSP Ki Database
LigandPNGBDBM50244035(cid_105078 | Beta CCE | CHEMBL454606 | ethyl 9H-py...)
Affinity DataKi:  0.600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
University Clinic For Psychiatry

Curated by PDSP Ki Database
LigandPNGBDBM50244035(cid_105078 | Beta CCE | CHEMBL454606 | ethyl 9H-py...)
Affinity DataKi:  1nMAssay Description:Binding affinity to human recombinant GABAA alpha1 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
University Clinic For Psychiatry

Curated by PDSP Ki Database
LigandPNGBDBM50244035(cid_105078 | Beta CCE | CHEMBL454606 | ethyl 9H-py...)
Affinity DataKd:  1nMAssay Description:Binding affinity to GABAA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50244035(cid_105078 | Beta CCE | CHEMBL454606 | ethyl 9H-py...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant GABAA alpha-1-beta-3-gamma-2 receptor expressed in HEK cells by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50244035(cid_105078 | Beta CCE | CHEMBL454606 | ethyl 9H-py...)
Affinity DataKi:  4.90nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant GABAA alpha-2-beta-3-gamma-2 receptor expressed in HEK cells by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
Univ. Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50244035(cid_105078 | Beta CCE | CHEMBL454606 | ethyl 9H-py...)
Affinity DataKi:  5nMAssay Description:Binding affinity to human recombinant GABAA alpha2 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50244035(cid_105078 | Beta CCE | CHEMBL454606 | ethyl 9H-py...)
Affinity DataKi:  5.70nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant GABAA alpha-3-beta-3-gamma-2 receptor expressed in HEK cells by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3(Human)
Univ. Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50244035(cid_105078 | Beta CCE | CHEMBL454606 | ethyl 9H-py...)
Affinity DataKi:  6nMAssay Description:Binding affinity to human recombinant GABAA alpha3 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50244035(cid_105078 | Beta CCE | CHEMBL454606 | ethyl 9H-py...)
Affinity DataKi:  26.8nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant GABAA alpha-5-beta-3-gamma-2 receptor expressed in HEK cells by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Univ. Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50244035(cid_105078 | Beta CCE | CHEMBL454606 | ethyl 9H-py...)
Affinity DataKi:  27nMAssay Description:Binding affinity to human recombinant GABAA alpha5 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Univ. Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50244035(cid_105078 | Beta CCE | CHEMBL454606 | ethyl 9H-py...)
Affinity DataKd:  27nMAssay Description:Binding affinity to GABAA alpha-5-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4(Human)
University Clinic For Psychiatry

Curated by PDSP Ki Database
LigandPNGBDBM50244035(cid_105078 | Beta CCE | CHEMBL454606 | ethyl 9H-py...)
Affinity DataKi:  693nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244035(cid_105078 | Beta CCE | CHEMBL454606 | ethyl 9H-py...)
Affinity DataIC50: 794nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4(Human)
University Clinic For Psychiatry

Curated by PDSP Ki Database
LigandPNGBDBM50244035(cid_105078 | Beta CCE | CHEMBL454606 | ethyl 9H-py...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity to human recombinant GABAA alpha4 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6(Rat)
National Institute of Diabetes, Digestive and Kidney Diseases

Curated by PDSP Ki Database
LigandPNGBDBM50244035(cid_105078 | Beta CCE | CHEMBL454606 | ethyl 9H-py...)
Affinity DataKi:  2.62E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6(Human)
Univ. Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50244035(cid_105078 | Beta CCE | CHEMBL454606 | ethyl 9H-py...)
Affinity DataKi:  2.70E+3nMAssay Description:Binding affinity to human recombinant GABAA alpha6 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50244035(cid_105078 | Beta CCE | CHEMBL454606 | ethyl 9H-py...)
Affinity DataKi:  2.70E+3nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant GABAA alpha-6-beta-3-gamma-2 receptor expressed in HEK cells by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
LigandPNGBDBM50244035(cid_105078 | Beta CCE | CHEMBL454606 | ethyl 9H-py...)
Affinity DataKi:  2.92E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6(Human)
Univ. Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50244035(cid_105078 | Beta CCE | CHEMBL454606 | ethyl 9H-py...)
Affinity DataKi:  4.46E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details Article
PubMed
TargetDiphosphomevalonate decarboxylase(Streptococcus pneumoniae D39)
Srmlsc

Curated by PubChem BioAssay
LigandPNGBDBM50244035(cid_105078 | Beta CCE | CHEMBL454606 | ethyl 9H-py...)
Affinity DataIC50: 4.94E+4nMAssay Description:Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2011
Entry Details
PCBioAssay