BDBM50308060 16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaen-3-one::CEP-701::CHEMBL603469::US11370779, Compound CEP-701

SMILES C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4C(=O)NCc4c4c5ccccc5n2c4c13

InChI Key InChIKey=UIARLYUEJFELEN-LROUJFHJSA-N

Data  11 IC50  804 Kd

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 815 hits for monomerid = 50308060   

TargetSerine/threonine-protein kinase SIK3 [59-1321](Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  120nMAssay Description:Binding affinity to QSKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  200nMAssay Description:Binding affinity to PIM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDeath-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  80nMAssay Description:Binding affinity to DAPK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCalcium/calmodulin-dependent protein kinase type 1D(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  47nMAssay Description:Binding affinity to CAMK1DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  350nMAssay Description:Binding affinity to PIK3CGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 15(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  1.30E+3nMAssay Description:Binding affinity to PFTAIRE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Nek7(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  4.00E+3nMAssay Description:Binding affinity to NEK7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRibosomal protein S6 kinase alpha-1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  62nMAssay Description:Binding affinity to RPS6KA4(Kin.Dom.1-N-terminal)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSTE20-like serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  35nMAssay Description:Binding affinity to SLKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  8.5nMAssay Description:Binding affinity to FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEphrin type-B receptor 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to EPHB4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEphrin type-B receptor 6(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  98nMAssay Description:Binding affinity to EPHB6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInterleukin-1 receptor-associated kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  6.10nMAssay Description:Binding affinity to IRAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase N2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  1.80nMAssay Description:Binding affinity to PKN2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase 17A(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  3.40nMAssay Description:Binding affinity to DRAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  110nMAssay Description:Binding affinity to CSF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProtein kinase C epsilon type(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  160nMAssay Description:Binding affinity to PRKCEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to RIPK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase kinase kinase 15(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  3.40nMAssay Description:Binding affinity to MAP3K15More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetLeukocyte tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  490nMAssay Description:Binding affinity to LTKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDual specificity protein kinase CLK4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  3nMAssay Description:Binding affinity to CLK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  210nMAssay Description:Binding affinity to CHEK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase receptor Tie-1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  680nMAssay Description:Binding affinity to TIE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRAC-alpha serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  4.40E+3nMAssay Description:Binding affinity to AKT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase PAK 2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  43nMAssay Description:Binding affinity to PAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase 32B(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  5.90E+3nMAssay Description:Binding affinity to YANK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEphrin type-A receptor 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  380nMAssay Description:Binding affinity to EPHA1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to MUSKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSTE20/SPS1-related proline-alanine-rich protein kinase(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to STK39More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMyosin light chain kinase, smooth muscle(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  12nMAssay Description:Binding affinity to MLCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  23nMAssay Description:Binding affinity to MAP4K4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCasein kinase I isoform gamma-1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to CSNK1G1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 8(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to CDK8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase LATS2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  1nMAssay Description:Binding affinity to LATS2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRibosomal protein S6 kinase alpha-4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  28nMAssay Description:Binding affinity to RPS6KA1(Kin.Dom.1-N-terminal)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 19(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to CDK11More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  9nMAssay Description:Binding affinity to IKK-alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProtein-tyrosine kinase 6(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  1.70E+3nMAssay Description:Binding affinity to BRKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBone morphogenetic protein receptor type-1B(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  57nMAssay Description:Binding affinity to BMPR1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase ULK1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to ULK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  6.60nMAssay Description:Binding affinity to TNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  32nMAssay Description:Binding affinity to ANKK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase kinase kinase 20(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to ZAKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetActivin receptor type-2A(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  2.50E+3nMAssay Description:Binding affinity to ACVR2AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  230nMAssay Description:Binding affinity to METMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSRSF protein kinase 3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  13nMAssay Description:Binding affinity to SRPK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRibosomal protein S6 kinase beta-1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  200nMAssay Description:Binding affinity to SBK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase MARK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  14nMAssay Description:Binding affinity to MARK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase MRCK beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to MRCKBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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