BDBM36371 5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidazolidinone, Nec-1::CID2828334::US10501473, Comparative Example 1
SMILES CN1C(=S)NC(Cc2c[nH]c3ccccc23)C1=O
InChI Key InChIKey=TXUWMXQFNYDOEZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 36371
Affinity DataKi: 1.14E+4nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 1.14E+4nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 1.14E+4nMAssay Description:Inhibition of human recombinant IDO assessed as inhibition of indoleamine 2,3-dioxygenase to kynurenine conversion after 60 mins by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.20E+4nMAssay Description:Competitive inhibition of 6His-tagged human recombinant IDO expressed in Escherichia coli BL21DE3pLysMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 182nMAssay Description:Inhibition of recombinant human GST-fused RIPK1 (1 to 497 residues) expressed in baculovirus infected insect Sf9 cells in presence of 32P-gamma-ATP a...More data for this Ligand-Target Pair
Affinity DataIC50: 1.15E+5nMAssay Description:Inhibition of recombinant human IDO using L-tryptophan as substrate after 60 minsMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 760nMAssay Description:Inhibition of recombinant GST-tagged RIP1 (unknown origin) after 4 hrs by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 1.14E+3nMAssay Description:Inhibition of human RIPK1 incubated for 40 min in presence of ATP by ADP-Glo luminescence kinase assayMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataEC50: 182nMpH: 7.3 T: 30°CAssay Description:In vitro kinase assay using RIP1More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of IDO (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant human IDO using L-Trp as substrate incubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 7.69E+4nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 7.69E+4nMAssay Description:Inhibition of human recombinant His6-tagged IDO1 expressed in Escherichia coli strain BL21DE3pLysMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at AHR in human HepG2-Lucia AhR cells stably transfected with DRE by luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.69E+4nMAssay Description:Inhibition of human recombinant IDO assessed as inhibition of indoleamine 2,3-dioxygenase to kynurenine conversion after 60 mins by HPLC analysisMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 95.5nMAssay Description:RIPK1 protein was over-expressed in HEK293 cell line, to which lysis buffer (50 mM Tris-Cl [pH 8.0], 150 mM NaCl, 1 mM EDTA, 1% NP-40, 0.4 mM phenylm...More data for this Ligand-Target Pair