BDBM50367032 COFORMYCIN

SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2[C@H](O)CNC=Nc12

InChI Key InChIKey=YOOVTUPUBVHMPG-LODYRLCVSA-N

Data  11 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50367032   

TargetAdenosine deaminase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50367032(COFORMYCIN)
Affinity DataKi:  0.0100nMAssay Description:The compound was tested in vitro for inhibition of human erythrocytic adenosine deaminaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine deaminase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50367032(COFORMYCIN)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity to ADA (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetAdenosine deaminase(Bovine)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50367032(COFORMYCIN)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity towards calf spleen adenosine deaminase was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine deaminase(malaria parasite P. falciparum)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50367032(COFORMYCIN)
Affinity DataKi:  0.0800nMAssay Description:Inhibition of Plasmodium falciparum N-terminal thrombin cleavable His6-tagged ADA expressed in Escherichia coli BL21 assessed as equilibrium dissocia...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine deaminase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50367032(COFORMYCIN)
Affinity DataKi:  0.100nMAssay Description:Compound was evaluated for the inhibition of adenosine deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine deaminase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50367032(COFORMYCIN)
Affinity DataKi:  0.110nMAssay Description:Inhibition of human erythrocytes ADA assessed as equilibrium dissociation constant by measuring reduction in formation of inosine using adenosine as ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine deaminase(malaria parasite P. falciparum)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50367032(COFORMYCIN)
Affinity DataKi:  0.25nMAssay Description:Inhibition of Plasmodium falciparum ADA assessed as reduction in formation of ammonia using adenosine as substrate incubated for 15 mins by spectroph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine deaminase(malaria parasite P. falciparum)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50367032(COFORMYCIN)
Affinity DataKi:  0.680nMAssay Description:Inhibition of Plasmodium falciparum N-terminal thrombin cleavable His6-tagged ADA expressed in Escherichia coli BL21 assessed as reduction in formati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine deaminase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50367032(COFORMYCIN)
Affinity DataKi:  14nMAssay Description:Inhibition of human erythrocytes ADA assessed as reduction in formation of inosine using adenosine as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine deaminase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50367032(COFORMYCIN)
Affinity DataKi:  1.29E+5nMAssay Description:Inhibition of adenosine deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine deaminase(Bovine)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50367032(COFORMYCIN)
Affinity DataKi:  1.00E+9nMAssay Description:Binding affinity (Ki) at calf intestinal adenosine deaminase.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed