BDBM50095953 CHEMBL3593776

SMILES NC(=O)c1cnc2[nH]ccc2c1NC1CCN(CC1)c1ccc(nn1)C#N

InChI Key InChIKey=MYAYQWJSZQGEAN-OVUBTYCDSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50095953   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50095953(CHEMBL3593776)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ERG expressed in CHOK1 cells incubated for 10 mins by Rb efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50095953(CHEMBL3593776)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human JAK3 kinase domain using biotin-Lyn-substrate-2 as substrate incubated for 1 hr by ELISA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50095953(CHEMBL3593776)
Affinity DataIC50:  22nMAssay Description:Inhibition of human JAK1 kinase domain using biotin-Lyn-substrate-2 as substrate incubated for 1 hr by ELISA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50095953(CHEMBL3593776)
Affinity DataIC50:  12nMAssay Description:Inhibition of human JAK2 kinase domain using biotin-Lyn-substrate-2 as substrate incubated for 1 hr by ELISA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed