BDBM50299218 8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydroxyphenyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione::CHEMBL566515::Cpd66

SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1cc(O)ccc1C

InChI Key InChIKey=JTWMOWRMSZZHDR-UHFFFAOYSA-N

Data  19 IC50  1 Kd

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50299218   

TargetEphrin type-A receptor 2 [596-900](Human)
Technical University of Munich

LigandPNGBDBM50299218(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)
Affinity DataKd:  19nMAssay Description:Kinobeads competition assays were performed in 96-well format as previously described using mixed protein lysates of four cancer cell lines (K-562, M...More data for this Ligand-Target Pair
TargetEphrin type-B receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50299218(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)
Affinity DataIC50:  5nMAssay Description:Inhibition of EphB4 (unknown origin) using Z'-LYTE TYR-1 peptide as substrate after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 1(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50299218(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of EphA1 by [gamma33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50299218(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)
Affinity DataIC50:  5nMAssay Description:Inhibition of EphB4 assessed as blockade of synthetic substrate phosphorylation by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50299218(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of EphA2 by [gamma33-P]ATP based assayMore data for this Ligand-Target Pair
TargetEphrin type-A receptor 3(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50299218(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)
Affinity DataIC50:  40nMAssay Description:Inhibition of EphA3 by [gamma33-P]ATP based assayMore data for this Ligand-Target Pair
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50299218(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of EphA4 by [gamma33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 5(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50299218(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)
Affinity DataIC50:  3nMAssay Description:Inhibition of EphA5 by [gamma33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 7(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50299218(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)
Affinity DataIC50:  1.12E+3nMAssay Description:Inhibition of EphA7 by [gamma33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 8(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50299218(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of EphA8 by [gamma33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 1(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50299218(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of EphB1 by [gamma33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50299218(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of EphB2 by [gamma33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 3(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50299218(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)
Affinity DataIC50:  15nMAssay Description:Inhibition of EphB3 by [gamma33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50299218(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of EphB4 by [gamma33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50299218(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of Lck (unknown origin) using [gamma-33P]ATP after 30 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50299218(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of Src (unknown origin) using [gamma-33P]ATP after 30 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50299218(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)
Affinity DataIC50:  0.920nMAssay Description:Inhibition of Abl (unknown origin) using [gamma-33P]ATP after 30 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50299218(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)
Affinity DataIC50:  130nMAssay Description:Inhibition of human myc-tagged full length EphB4 expressed in MEF cells assessed as inhibition of ephrinB2-Fc-induced autophosphorylation incubated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50299218(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of EphB4 (unknown origin) using [gamma-33P]ATP by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 2 [596-900](Human)
Technical University of Munich

LigandPNGBDBM50299218(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)
Affinity DataIC50:  1nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair