BDBM410060 D2190::US10370360, Example 12

SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1ccc(CN2CCN(C)CC2)c(c1)C(F)(F)F)c1cncnc1

InChI Key InChIKey=PGNPRFGVXQKJFG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 410060   

TargetEpithelial discoidin domain-containing receptor 1(Human)
University of Texas

US Patent
LigandPNGBDBM410060(D2190 | US10370360, Example 12)
Affinity DataIC50: 19.9nMAssay Description:The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent

TargetDiscoidin domain-containing receptor 2(Human)
University of Texas

US Patent
LigandPNGBDBM410060(D2190 | US10370360, Example 12)
Affinity DataIC50: 334nMAssay Description:The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent

TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of Texas

US Patent
LigandPNGBDBM410060(D2190 | US10370360, Example 12)
Affinity DataIC50: 546nMAssay Description:The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
University of Texas

US Patent
LigandPNGBDBM410060(D2190 | US10370360, Example 12)
Affinity DataIC50: 1.00E+4nMAssay Description:The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent