BDBM26470 3-({4-[(2-benzyl-3-methyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)benzene-1-sulfonamide::3-aminobenzene sulfonamide, 12d::D3RKN_49

SMILES CN(c1ccc2c(C)n(Cc3ccccc3)nc2c1)c1ccnc(Nc2cccc(c2)S(N)(=O)=O)n1

InChI Key InChIKey=MGWSCJCLMDQNGB-UHFFFAOYSA-N

Data  5 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 26470   

LigandPNGBDBM26470(3-({4-[(2-benzyl-3-methyl-2H-indazol-6-yl)(methyl)...)
Affinity DataIC50:  2.60nMpH: 7.5 T: 22°CAssay Description:The assay uses purified baculovirus-expressed GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C9(Human)
Gsk

LigandPNGBDBM26470(3-({4-[(2-benzyl-3-methyl-2H-indazol-6-yl)(methyl)...)
Affinity DataIC50:  500nMpH: 7.4 T: 37°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C19(Human)
Gsk

LigandPNGBDBM26470(3-({4-[(2-benzyl-3-methyl-2H-indazol-6-yl)(methyl)...)
Affinity DataIC50:  1.40E+3nMpH: 7.4 T: 37°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM26470(3-({4-[(2-benzyl-3-methyl-2H-indazol-6-yl)(methyl)...)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2023More data for this Ligand-Target Pair
In DepthDetails D3R


TargetCytochrome P450 3A4(Human)
Gsk

LigandPNGBDBM26470(3-({4-[(2-benzyl-3-methyl-2H-indazol-6-yl)(methyl)...)
Affinity DataIC50:  7.90E+4nMAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM26470(3-({4-[(2-benzyl-3-methyl-2H-indazol-6-yl)(methyl)...)
Affinity DataKd:  14nMAssay Description:D3R2021More data for this Ligand-Target Pair
In DepthDetails D3R


TargetTyrosine-protein kinase JAK2(Human)
D3R/Abbott

LigandPNGBDBM26470(3-({4-[(2-benzyl-3-methyl-2H-indazol-6-yl)(methyl)...)
Affinity DataKd:  1.50E+3nMAssay Description:D3R2022More data for this Ligand-Target Pair
In DepthDetails D3R


TargetCytochrome P450 2D6(Human)
Gsk

LigandPNGBDBM26470(3-({4-[(2-benzyl-3-methyl-2H-indazol-6-yl)(methyl)...)
Affinity DataIC50:  6.60E+4nMAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed