BDBM50350476 BRL-1702::DICLOXACILLIN

SMILES Cc1onc(c1C(=O)N[C@H]1[C@H]2SC(C)(C)[C@@H](N2C1=O)C(O)=O)-c1c(Cl)cccc1Cl

InChI Key InChIKey=YFAGHNZHGGCZAX-JKIFEVAISA-N

Data  4 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50350476   

TargetSolute carrier family 15 member 2(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50350476(BRL-1702 | DICLOXACILLIN)
Affinity DataKi:  4.20E+5nMAssay Description:Binding affinity to human PepT2 in SKTP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetSolute carrier family 15 member 2(Rat)
Biozentrum of The Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50350476(BRL-1702 | DICLOXACILLIN)
Affinity DataKi:  4.20E+5nMAssay Description:TP_TRANSPORTER: inhibition of Gly-Sar uptake (pH6.0) in SKPT cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 15 member 1(Human)
Biozentrum of The Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50350476(BRL-1702 | DICLOXACILLIN)
Affinity DataKi:  7.20E+6nMAssay Description:TP_TRANSPORTER: inhibition of Gly-Sar uptake (pH6.0) in Caco-2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetSolute carrier family 15 member 1(Human)
Biozentrum of The Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50350476(BRL-1702 | DICLOXACILLIN)
Affinity DataKi:  7.20E+6nMAssay Description:Binding affinity against membrane transport protein PEPT1 in human Caco-2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


LigandPNGBDBM50350476(BRL-1702 | DICLOXACILLIN)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50350476(BRL-1702 | DICLOXACILLIN)
Affinity DataIC50:  6.97E+4nMAssay Description:Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50350476(BRL-1702 | DICLOXACILLIN)
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50350476(BRL-1702 | DICLOXACILLIN)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50350476(BRL-1702 | DICLOXACILLIN)
Affinity DataIC50:  5.64E+4nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBile salt export pump(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50350476(BRL-1702 | DICLOXACILLIN)
Affinity DataIC50:  1.11E+5nMAssay Description:Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate up...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50350476(BRL-1702 | DICLOXACILLIN)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 8(Mouse)
Wilkes University

Curated by ChEMBL
LigandPNGBDBM50350476(BRL-1702 | DICLOXACILLIN)
Affinity DataIC50:  1.66E+4nMAssay Description:Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50350476(BRL-1702 | DICLOXACILLIN)
Affinity DataIC50:  4.50E+4nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed