BDBM23414 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one::Diosmetin::Diosmetin (25)

SMILES COc1ccc(cc1O)-c1cc(=O)c2c(O)cc(O)cc2o1

InChI Key InChIKey=MBNGWHIJMBWFHU-UHFFFAOYSA-N

Data  3 KI  11 IC50  1 Other

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 23414   

TargetCytochrome P450 1B1(Human)
University of Crete

Curated by ChEMBL
LigandPNGBDBM23414(5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chr...)
Affinity DataKi:  16nMAssay Description:Inhibition of CYP1B1 EROD activity assessed as inhibition of deethylation of 7-ethoxyresorufin to resorufinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Human)
University of Crete

Curated by ChEMBL
LigandPNGBDBM23414(5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chr...)
Affinity DataKi:  16nMAssay Description:Inhibition of CYP1B1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A1(Human)
University of Crete

Curated by ChEMBL
LigandPNGBDBM23414(5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chr...)
Affinity DataKi:  89nMAssay Description:Inhibition of CYP1A1 EROD activity assessed as inhibition of deethylation of 7-ethoxyresorufin to resorufinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Human)
Konkuk University

LigandPNGBDBM23414(5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chr...)
Affinity DataIC50:  3.86E+3nMAssay Description:The kinase assay was performed using the EMD Millipore KinaseProfiler service assay protocol. Aurora B kinase was supplied by EMD Millipore Corp. The...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Human)
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM23414(5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chr...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of MRP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Human)
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM23414(5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chr...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of MRP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Human)
University of Shizuoka

Curated by ChEMBL
LigandPNGBDBM23414(5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chr...)
Affinity DataIC50:  2.44E+3nMAssay Description:Inhibition of human CYP1A2 by EROD assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A1(Human)
University of Crete

Curated by ChEMBL
LigandPNGBDBM23414(5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chr...)
Affinity DataIC50:  140nMAssay Description:Inhibition of human CYP1A1 by EROD assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Human)
University of Crete

Curated by ChEMBL
LigandPNGBDBM23414(5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chr...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human CYP1B1 by EROD assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM23414(5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chr...)
Affinity DataIC50:  2.79E+4nMAssay Description:Inhibition of LSD1 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol polyphosphate multikinase(Human)
National Institute of Environmental Health Sciences

Curated by ChEMBL
LigandPNGBDBM23414(5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chr...)
Affinity DataIC50:  7.20E+3nMAssay Description:Inhibition of human IPMK using insP3 as substrate preincubated for 15 mins followed by substrate and measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 10(Human)
Eberhard Karls University of Tuebingen

LigandPNGBDBM23414(5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chr...)
Affinity DataIC50:  2.86E+4nMT: 37°CAssay Description:The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol hexakisphosphate kinase 2(Human)
National Institute of Environmental Health Sciences

Curated by ChEMBL
LigandPNGBDBM23414(5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chr...)
Affinity DataIC50:  900nMAssay Description:Inhibition of human IP6K2 using insP6 as substrate preincubated for 15 mins followed by substrate and measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-amylase 1A(Human)
Nestle Research Center

LigandPNGBDBM23414(5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chr...)
Affinity DatapH: 6.0 T: 22°CAssay Description:The assay was carried out at room temperature for 10 min with salivary alpha-amylase, starch, and test compounds. The reducing sugar was determined b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Human)
Eberhard Karls University of Tuebingen

LigandPNGBDBM23414(5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chr...)
Affinity DataIC50:  2.32E+4nMT: 37°CAssay Description:The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed