BDBM283999 E25::US10023564, Example 25

SMILES CC1=C(C(=O)Nc2ccc3[nH]ncc3c2)C(c2ccc(F)c(C(=O)NC3CC4CC5(C)C4(C)C35C)c2)NC(=O)N1

InChI Key InChIKey=YUEMQXXPOWFWGA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 283999   

TargetBeta-adrenergic receptor kinase 1(Human)
University of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 283999BDBM283999(US10023564, Example 25 | E25)
Affinity DataIC50: 5.20E+3nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2019
Entry Details
US Patent

TargetG protein-coupled receptor kinase 5(Human)
University of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 283999BDBM283999(US10023564, Example 25 | E25)
Affinity DataIC50: 8.90E+4nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2019
Entry Details
US Patent

TargetRhodopsin kinase GRK1(Human)
University of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 283999BDBM283999(US10023564, Example 25 | E25)
Affinity DataIC50: 1.00E+5nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2019
Entry Details
US Patent