BDBM50209683 (R)-2-(4-(9-bromo-2,3-dimethylnaphtho[2,3-b]thiophen-4-yl)-2,6-dimethylphenoxy)-3-phenylpropanoic acid::2-[4-(9-Bromo-2,3-dimethyl-naphtho[2,3-b]thiophen-4-yl)-2,6-dimethyl-phenoxy]-3-phenyl-propionic acid::CHEMBL184041::Ertiprotafib

SMILES Cc1sc2c(Br)c3ccccc3c(-c3cc(C)c(O[C@H](Cc4ccccc4)C(O)=O)c(C)c3)c2c1C

InChI Key InChIKey=FONCZICQWCUXEB-RUZDIDTESA-N

Data  1 KI  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50209683   

TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50209683((R)-2-(4-(9-bromo-2,3-dimethylnaphtho[2,3-b]thioph...)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition of PTP1B after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50209683((R)-2-(4-(9-bromo-2,3-dimethylnaphtho[2,3-b]thioph...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50209683((R)-2-(4-(9-bromo-2,3-dimethylnaphtho[2,3-b]thioph...)
Affinity DataIC50:  400nMAssay Description:Inhibition of IKKbeta after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50209683((R)-2-(4-(9-bromo-2,3-dimethylnaphtho[2,3-b]thioph...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50209683((R)-2-(4-(9-bromo-2,3-dimethylnaphtho[2,3-b]thioph...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50209683((R)-2-(4-(9-bromo-2,3-dimethylnaphtho[2,3-b]thioph...)
Affinity DataIC50:  410nMAssay Description:Inhibition of PTB1B using pNPP as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50209683((R)-2-(4-(9-bromo-2,3-dimethylnaphtho[2,3-b]thioph...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of human recombinant PTP1B (1 to 322 residues) expressed in Escherichia coli using pNPP as substrate preincubated with substrate for 10 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50209683((R)-2-(4-(9-bromo-2,3-dimethylnaphtho[2,3-b]thioph...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of PTP1B after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50209683((R)-2-(4-(9-bromo-2,3-dimethylnaphtho[2,3-b]thioph...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of PTP1B by pNPP hydrolase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50209683((R)-2-(4-(9-bromo-2,3-dimethylnaphtho[2,3-b]thioph...)
Affinity DataIC50:  384nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50209683((R)-2-(4-(9-bromo-2,3-dimethylnaphtho[2,3-b]thioph...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of human recombinant PTP1B (1 to 299 residues) expressed in Escherichia coli using pNPP as substrate preincubated for 30 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50209683((R)-2-(4-(9-bromo-2,3-dimethylnaphtho[2,3-b]thioph...)
Affinity DataIC50:  384nMAssay Description:Inhibition of recombinant human PTP1B (1 to 299) expressed in Escherichia coli using p-nitrophenyl phosphate as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50209683((R)-2-(4-(9-bromo-2,3-dimethylnaphtho[2,3-b]thioph...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of PTP1B after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed