BDBM81984 CAS_29110-47-2::Guanfacine::NSC_3519

SMILES NC(=N)NC(=O)Cc1c(Cl)cccc1Cl

InChI Key InChIKey=INJOMKTZOLKMBF-UHFFFAOYSA-N

Data  10 KI  5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 81984   

TargetNischarin(Human)
University of Belgrade

Curated by ChEMBL

LigandBDBM81984(CAS_29110-47-2 | Guanfacine | NSC_3519)Copy SMILESCopy InChI

Affinity DataKi:  19.0nMAssay Description:Displacement of [125I]PIC from human imidazoline receptor 1 in human platelets analyzed under norepinephrine mask of alpha 2ARMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseDrugBankMCE
KEGGPC cidPC sidPatents

In DepthDetails ArticlePubMed
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TargetAlpha-2A adrenergic receptor(Mouse)
Roche Bioscience

Curated by PDSP K_i Database

LigandBDBM81984(CAS_29110-47-2 | Guanfacine | NSC_3519)Copy SMILESCopy InChI

Affinity DataKi:  20.4nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseDrugBankMCE
KEGGPC cidPC sidPatents

In DepthDetails ArticlePubMed
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TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP K_i Database

LigandBDBM81984(CAS_29110-47-2 | Guanfacine | NSC_3519)Copy SMILESCopy InChI

Affinity DataKi:  24.9nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseDrugBankMCE
KEGGPC cidPC sidPatents

In DepthDetails PubMed
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TargetAlpha-2A adrenergic receptor(Human)
University of Michigan

Curated by PDSP K_i Database

LigandBDBM81984(CAS_29110-47-2 | Guanfacine | NSC_3519)Copy SMILESCopy InChI

Affinity DataKi:  50.3nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseDrugBankMCE
KEGGPC cidPC sidPatents

In DepthDetails PubMed
Copy BDB DOI
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TargetAlpha-2A adrenergic receptor(Human)
University of Michigan

Curated by PDSP K_i Database

LigandBDBM81984(CAS_29110-47-2 | Guanfacine | NSC_3519)Copy SMILESCopy InChI

Affinity DataKi:  93.3nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseDrugBankMCE
KEGGPC cidPC sidPatents

In DepthDetails ArticlePubMed
Copy BDB DOI
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TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP K_i Database

LigandBDBM81984(CAS_29110-47-2 | Guanfacine | NSC_3519)Copy SMILESCopy InChI

Affinity DataKi:  340nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseDrugBankMCE
KEGGPC cidPC sidPatents

In DepthDetails PubMed
Copy BDB DOI
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TargetAlpha-2B adrenergic receptor(Human)
University of Michigan

Curated by PDSP K_i Database

LigandBDBM81984(CAS_29110-47-2 | Guanfacine | NSC_3519)Copy SMILESCopy InChI

Affinity DataKi:  1.02E+3nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseDrugBankMCE
KEGGPC cidPC sidPatents

In DepthDetails PubMed
Copy BDB DOI
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TargetAlpha-2C adrenergic receptor(Human)
University of Michigan

Curated by PDSP K_i Database

LigandBDBM81984(CAS_29110-47-2 | Guanfacine | NSC_3519)Copy SMILESCopy InChI

Affinity DataKi:  1.12E+3nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseDrugBankMCE
KEGGPC cidPC sidPatents

In DepthDetails PubMed
Copy BDB DOI
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TargetAlpha-2B adrenergic receptor(Human)
University of Michigan

Curated by PDSP K_i Database

LigandBDBM81984(CAS_29110-47-2 | Guanfacine | NSC_3519)Copy SMILESCopy InChI

Affinity DataKi:  1.38E+3nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseDrugBankMCE
KEGGPC cidPC sidPatents

In DepthDetails ArticlePubMed
Copy BDB DOI
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TargetAlpha-2C adrenergic receptor(Human)
University of Michigan

Curated by PDSP K_i Database

LigandBDBM81984(CAS_29110-47-2 | Guanfacine | NSC_3519)Copy SMILESCopy InChI

Affinity DataKi:  3.89E+3nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseDrugBankMCE
KEGGPC cidPC sidPatents

In DepthDetails ArticlePubMed
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TargetATP-binding cassette sub-family C member 3(Human)
Amgen

Curated by ChEMBL

LigandBDBM81984(CAS_29110-47-2 | Guanfacine | NSC_3519)Copy SMILESCopy InChI

Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseDrugBankMCE
KEGGPC cidPC sidPatents

In DepthDetails ArticlePubMed
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TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL

LigandBDBM81984(CAS_29110-47-2 | Guanfacine | NSC_3519)Copy SMILESCopy InChI

Affinity DataIC50: >1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseDrugBankMCE
KEGGPC cidPC sidPatents

In DepthDetails ArticlePubMed
Copy BDB DOI
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TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL

LigandBDBM81984(CAS_29110-47-2 | Guanfacine | NSC_3519)Copy SMILESCopy InChI

Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseDrugBankMCE
KEGGPC cidPC sidPatents

In DepthDetails ArticlePubMed
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TargetATP-binding cassette sub-family C member 2(Human)
Amgen

Curated by ChEMBL

LigandBDBM81984(CAS_29110-47-2 | Guanfacine | NSC_3519)Copy SMILESCopy InChI

Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseDrugBankMCE
KEGGPC cidPC sidPatents

In DepthDetails ArticlePubMed
Copy BDB DOI
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TargetATP-binding cassette sub-family C member 4(Human)
Amgen

Curated by ChEMBL

LigandBDBM81984(CAS_29110-47-2 | Guanfacine | NSC_3519)Copy SMILESCopy InChI

Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseDrugBankMCE
KEGGPC cidPC sidPatents

In DepthDetails ArticlePubMed
Copy BDB DOI
Copy reaction URL