BDBM50649855 Surufatinib::Hmpl-012::Sulfatinib::HMPL-012

SMILES Cc1cc2cc(Oc3ccnc(Nc4cccc(CS(=O)(=O)NCCN(C)C)c4)n3)ccc2[nH]1

InChI Key

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50649855   

TargetVascular endothelial growth factor receptor 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 1nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 1nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 1nMAssay Description:Inhibition of VEGFR3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 1nMAssay Description:Inhibition of VEGFR-3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 2nMAssay Description:Inhibition of VEGFR-1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Mer(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 4nMAssay Description:Inhibition of human MERTK by discoverX kinome scan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 15nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 15nMAssay Description:Inhibition of FGFR1 (unknown origin) by trFRET binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 24nMAssay Description:Inhibition of VEGFR-2 (unknown origin) in presence of ATP incubated for 45 mins by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 41nMAssay Description:Inhibition of TRKB (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 41nMAssay Description:Inhibition of TRKB (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 67nMAssay Description:Inhibition of FLT3 (unknown origin) by enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 67nMAssay Description:Inhibition of wild type FLT3 (unknown origin) phosphorylation in human RS4-11 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 79nMAssay Description:Inhibition of CSF1R in mouse RAW264.7 cells assessed as reduction in AKT phosphorylation measured after 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed