BDBM50005147 (S)-1-{(S)-2-[4-(4-Bromo-benzenesulfonylaminocarbonyl)-benzoylamino]-3-methyl-butyryl}-pyrrolidine-2-carboxylic acid (3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-amide::1-{2-[4-(4-Bromo-benzenesulfonylaminocarbonyl)-benzoylamino]-3-methyl-butyryl}-pyrrolidine-2-carboxylic acid (3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-amide::CHEMBL3085439::ICI-200355

SMILES CC(C)C(NC(=O)c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(Br)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F

InChI Key InChIKey=UUWIYANOKPHUQZ-NTZARQNWSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50005147   

TargetNeutrophil elastase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50005147((S)-1-{(S)-2-[4-(4-Bromo-benzenesulfonylaminocarbo...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity for human leukocyte elastase (HLE); Kreact/KinactMore data for this Ligand-Target Pair
In DepthDetails Article

TargetNeutrophil elastase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50005147((S)-1-{(S)-2-[4-(4-Bromo-benzenesulfonylaminocarbo...)
Affinity DataKi:  0.400nMAssay Description:Ratio of Kreact to that of Kinact was determined on human leukocyte elastase(HLE)More data for this Ligand-Target Pair
In DepthDetails Article

TargetNeutrophil elastase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50005147((S)-1-{(S)-2-[4-(4-Bromo-benzenesulfonylaminocarbo...)
Affinity DataKi:  0.400nMAssay Description:Potency of Inhibition of human leukocyte elastase (HLE) expressed as apparent binding constantMore data for this Ligand-Target Pair
In DepthDetails Article

TargetNeutrophil elastase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50005147((S)-1-{(S)-2-[4-(4-Bromo-benzenesulfonylaminocarbo...)
Affinity DataKi:  0.620nMAssay Description:Inhibitory activity against Human Neutrophil Elastase using acute lung injury model (ALIM) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeutrophil elastase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50005147((S)-1-{(S)-2-[4-(4-Bromo-benzenesulfonylaminocarbo...)
Affinity DataIC50:  38nMAssay Description:In vitro inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed