BDBM50034043 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-propoxy}-3-methoxy-phenyl)-ethanone::CHEMBL14376::ILOPERIDONE

SMILES COc1cc(ccc1OCCCN1CCC(CC1)c1noc2cc(F)ccc12)C(C)=O

InChI Key InChIKey=XMXHEBAFVSFQEX-UHFFFAOYSA-N

Data  55 KI  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 67 hits for monomerid = 50034043   

Target5-hydroxytryptamine receptor 2A(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  0.120nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  0.310nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  0.350nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor [16-465](Rat)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataIC50: 0.400nMAssay Description:Binding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  2.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Hoechst Marion Roussel

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  3.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  3.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  5.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  6.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Hoechst Marion Roussel

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  7.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Bovine)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataIC50: 9nMAssay Description:Binding affinity against 5-hydroxytryptamine 2 receptor was determined using [ [3H]spiperone radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  12.3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  13.3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  14nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Hoechst Marion Roussel

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  14nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  15nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  16.2nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  21.4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Hoechst Marion Roussel

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  21.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  25nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  33nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Rat)
Hoechst Marion Roussel

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  42.7nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  42.8nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Hoechst Marion Roussel

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  54nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  63.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataIC50: 64nMAssay Description:Binding affinity against sigma receptor using [3H]-( +)-SKF10,047 radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Hoechst Marion Roussel

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataIC50: 110nMAssay Description:Affinity for dopamine receptor D2 binding sites by its ability to displace [3H]spiperone from rat striatum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataIC50: 110nMAssay Description:Binding affinity against Dopamine receptor D2 was determined using [ [3H]-spiperone radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  112nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  162nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  162nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Mouse)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataIC50: 210nMAssay Description:Binding affinity against 5-hydroxytryptamine 1A receptor was determined using [3H]-8-OH-DPAT radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Hoechst Marion Roussel

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  216nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
Hoechst Marion Roussel

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  319nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
Hoechst Marion Roussel

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  546nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Mouse)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataIC50: 750nMAssay Description:Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Rat)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor using [3H]quinuclidinyl benzilateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  1.48E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  2.95E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  3.31E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  4.90E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  6.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  8.32E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi:  9.33E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details Article
PubMed
TargetSubstance-K receptor(Human)
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details Article
PubMed
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