BDBM50293282 CHEMBL504535::Imrecoxib

SMILES CCCN1CC(=C(C1=O)c1ccc(C)cc1)c1ccc(cc1)S(C)(=O)=O

InChI Key InChIKey=AXMZZGKKZDJGAZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50293282   

TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Pharmaphase

Curated by ChEMBL
LigandPNGBDBM50293282(CHEMBL504535 | Imrecoxib)
Affinity DataIC50:  18nMAssay Description:Inhibition of LPS-induced COX-2 in peritoneal macrophage of C57BL/J6 mouse assessed as prostaglandin E2 formation preincubated for 1 hr followed by L...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Mus musculus)
Chinese Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50293282(CHEMBL504535 | Imrecoxib)
Affinity DataIC50:  114nMAssay Description:Inhibition of COX1 in mouse peritoneal macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Pharmaphase

Curated by ChEMBL
LigandPNGBDBM50293282(CHEMBL504535 | Imrecoxib)
Affinity DataIC50:  18nMAssay Description:Inhibition of COX2 in mouse peritoneal macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Mus musculus)
Chinese Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50293282(CHEMBL504535 | Imrecoxib)
Affinity DataIC50:  115nMAssay Description:Inhibition of calcimycin-induced COX-1 in peritoneal macrophage of C57BL/J6 mouse assessed as 6-Keto prostaglandin F1alpha formation preincubated for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed