BDBM50279987 2,3,5,6,7,8-Hexahydro-1H-cyclopenta[b]quinolin-9-ylamine::CHEMBL130880::Ipidacrine

SMILES C1CCc2c(c(c3c(n2)CCC3)N)C1

InChI Key InChIKey=YLUSMKAJIQOXPV-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50279987   

TargetCholinesterase(Horse)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50279987(Ipidacrine | 2,3,5,6,7,8-Hexahydro-1H-cyclopenta[b...)
Affinity DataIC50: 70nMAssay Description:Inhibition of equine serum BChE pre-incubated for 5 mins before butyrylthiocholineiodide substrate addition by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50279987(Ipidacrine | 2,3,5,6,7,8-Hexahydro-1H-cyclopenta[b...)
Affinity DataIC50: 170nMAssay Description:Inhibition of Electrophorus electricus AChE pre-incubated for 5 mins before acetylthiocholine iodide substrate addition by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50279987(Ipidacrine | 2,3,5,6,7,8-Hexahydro-1H-cyclopenta[b...)
Affinity DataIC50: 658nMAssay Description:In vitro inhibition of acetylcholinesterase isolated from human erythrocytes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetNucleosome-remodeling factor subunit BPTF(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50279987(Ipidacrine | 2,3,5,6,7,8-Hexahydro-1H-cyclopenta[b...)
Affinity DataIC50: 5.90E+5nMAssay Description:Inhibition of biotinylated-H3K4me2 binding to N-terminal His9 tagged human BPTF isoform 2 PHD (2722 to 2781 residues) expressed in Escherichia coli B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed