BDBM716454 JAK345::US20250034112, Compound 13

SMILES Nc1nc(Oc2ccc(CC(=O)C[C@@H](CCCc3ccccc3)C(=O)O)cc2)c2cc[nH]c2n1

InChI Key InChIKey=QIAWRZZBBFMFBT-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 716454   

TargetTyrosine-protein kinase JAK2 [536-812](Human)
Yale University

US Patent
LigandPNGBDBM716454(JAK345 | US20250034112, Compound 13)
Affinity DataKd:  33.4nMAssay Description:Binding affinities (Kd) with the JAK2 JH2 domain were evaluated using the previously developed FP assay and compound 1 as a control. An initial scree...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [536-812](Human)
Yale University

US Patent
LigandPNGBDBM716454(JAK345 | US20250034112, Compound 13)
Affinity DataIC50: 33.4nMAssay Description:Binding affinities (Kd) with the JAK2 JH2 domain were evaluated using the previously developed FP assay and compound 1 as a control. An initial scree...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [536-812,V617F](Human)
Yale University

US Patent
LigandPNGBDBM716454(JAK345 | US20250034112, Compound 13)
Affinity DataIC50: 43nMAssay Description:Binding affinities (Kd) with the JAK2 JH2 domain were evaluated using the previously developed FP assay and compound 1 as a control. An initial scree...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [536-812](Human)
Yale University

US Patent
LigandPNGBDBM716454(JAK345 | US20250034112, Compound 13)
Affinity DataKd:  587nMAssay Description:Binding affinities (Kd) with the JAK2 JH2 domain were evaluated using the previously developed FP assay and compound 1 as a control. An initial scree...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Yale University

US Patent
LigandPNGBDBM716454(JAK345 | US20250034112, Compound 13)
Affinity DataIC50: 6.81E+3nMAssay Description:Binding affinities (Kd) with the JAK2 JH2 domain were evaluated using the previously developed FP assay and compound 1 as a control. An initial scree...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent