BDBM50600089 KPT-9274::Kpt 9274::Kpt-9274::PADNARSERTIB::Padnarsertib::Pak4-in-1

SMILES Nc1ccc(\C=C\C(=O)NCc2cc3cc(cc(-c4ccc(F)cc4)c3o2)-c2ccc(cc2)C(=O)N2CCC(F)(F)CC2)cn1

InChI Key InChIKey=MRFOPLWJZULAQD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50600089   

TargetSerine/threonine-protein kinase PAK 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50600089(Padnarsertib | Kpt 9274 | Kpt-9274 | Pak4-in-1 | K...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PAK4 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50600089(Padnarsertib | Kpt 9274 | Kpt-9274 | Pak4-in-1 | K...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human PAK4 assessed as enzymatic activity incubated for 20 mins by filter binding methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50600089(Padnarsertib | Kpt 9274 | Kpt-9274 | Pak4-in-1 | K...)
Affinity DataIC50: 120nMAssay Description:Inhibition of NAMPT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed