BDBM50210557 CHEMBL242756::MCL-147

SMILES Nc1nc2cc3c(C[C@@H]4[C@@H]5CCCC[C@]35CCN4CC3CC3)cc2s1

InChI Key InChIKey=OQGLRMIBYLADSW-RRMPHLOHSA-N

Data  9 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50210557   

TargetKappa-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50210557(CHEMBL242756 | MCL-147)
Affinity DataKi:  0.0490nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50210557(CHEMBL242756 | MCL-147)
Affinity DataKi:  0.0490nMAssay Description:Antagonist activity at human kappa-opioid receptor expressed in CHO cells assessed as inhibition of U69593-induced [35S]GTPgammaS binding after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50210557(CHEMBL242756 | MCL-147)
Affinity DataKi:  0.0490nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50210557(CHEMBL242756 | MCL-147)
Affinity DataKi:  1.5nMAssay Description:Antagonist activity at human mu-opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-induced [35S]GTPgammaS binding after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50210557(CHEMBL242756 | MCL-147)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50210557(CHEMBL242756 | MCL-147)
Affinity DataKi:  1.5nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDelta-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50210557(CHEMBL242756 | MCL-147)
Affinity DataKi:  29nMAssay Description:Displacement of [3H]Naltrindole from human delta opioid receptor expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDelta-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50210557(CHEMBL242756 | MCL-147)
Affinity DataKi:  29nMAssay Description:Displacement of [3H]naltrindole from human delta-opioid receptor expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDelta-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50210557(CHEMBL242756 | MCL-147)
Affinity DataKi:  29nMAssay Description:Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50210557(CHEMBL242756 | MCL-147)
Affinity DataEC50:  2.40nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50210557(CHEMBL242756 | MCL-147)
Affinity DataEC50:  73nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed