BDBM50239401 3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine::CHEMBL256777::MERCK-544

SMILES C1C2CC3CC1CC(C2)(C3)c1nnc2CCCCCn12

InChI Key InChIKey=VFTQRHWULYJKCI-UHFFFAOYSA-N

Data  20 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50239401   

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50239401(3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]tria...)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50239401(3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]tria...)
Affinity DataIC50:  35nMAssay Description:Inhibition of mouse 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails PubMed

Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50239401(3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]tria...)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of human 11beta-HSD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50239401(3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]tria...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target11-beta-hydroxysteroid dehydrogenase type 2(Mouse)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50239401(3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]tria...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mouse 11beta-HSD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50239401(3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]tria...)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of 11beta-HSD1 (unknown origin) expressed in CHO-K1 cells assessed as conversion of [3H]cortisone to cortisol by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50239401(3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]tria...)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of human 11beta HSD1 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50239401(3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]tria...)
Affinity DataIC50:  98nMAssay Description:Inhibition of mouse 11beta HSD1 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50239401(3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]tria...)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of human 11beta HSD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target11-beta-hydroxysteroid dehydrogenase type 2(Mouse)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50239401(3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]tria...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mouse 11beta HSD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50239401(3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]tria...)
Affinity DataIC50: >3.30E+3nMAssay Description:Inhibition of 11beta-HSD2 (unknown origin) expressed in CHO-K1 cells assessed as conversion of [3H]cortisol to cortisone by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50239401(3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]tria...)
Affinity DataIC50:  7.5nMAssay Description:Displacement of [3H]cortisone from human 11beta-HSD1 expressed in baculovirus-infected Sf9 cells after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50239401(3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]tria...)
Affinity DataIC50:  97nMAssay Description:Displacement of [3H]cortisone from mouse 11beta-HSD1 expressed in baculovirus-infected Sf9 cells after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50239401(3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]tria...)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of human 11-beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50239401(3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]tria...)
Affinity DataIC50:  98nMAssay Description:Inhibition of mouse 11-beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50239401(3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]tria...)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of human 11-beta-HSD2 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target11-beta-hydroxysteroid dehydrogenase type 2(Mouse)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50239401(3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]tria...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mouse 11-beta-HSD2 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50239401(3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]tria...)
Affinity DataIC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2More data for this Ligand-Target Pair
In DepthDetails PubMed

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50239401(3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]tria...)
Affinity DataIC50:  7.70nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails PubMed

Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50239401(3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]tria...)
Affinity DataIC50:  97nMAssay Description:Inhibition of mouse 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed