BDBM50371400 MERIOLIN 5

SMILES CCCOc1ccnc2[nH]cc(-c3ccnc(N)n3)c12

InChI Key InChIKey=ZHMRPXZRUZLCNL-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50371400   

LigandPNGBDBM50371400(MERIOLIN 5)
Affinity DataIC50:  37nMAssay Description:Inhibition of rat recombinant GST-DYRK1A expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50371400(MERIOLIN 5)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant CDK2/cyclin A expressed in insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50371400(MERIOLIN 5)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of human recombinant CDK9/cyclin T expressed in insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 5 activator 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50371400(MERIOLIN 5)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant GST-CDK5/p25 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50371400(MERIOLIN 5)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant CDK2/cyclin A after 30 mins by [gamma-33P]ATP based scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetCyclin-dependent kinase 5 activator 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50371400(MERIOLIN 5)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant CDK5/p25 expressed in baculovirus infected Sf9 insect cells after 30 mins by [gamma-33P]ATP based scintillation count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50371400(MERIOLIN 5)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant CDK9/cyclin T expressed in baculovirus infected Sf9 insect cells using pRB (773 to 928 residues) as substrate after 3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed