BDBM318446 NSC332395::US9624235, Compound 4

SMILES CCn1c2ccccc2c2cc(\C=N\Nc3cc(C)nc4cc5OCOc5cc34)ccc12

InChI Key InChIKey=ZXPGMLVLRGBYBF-MZJWZYIUSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 318446   

TargetDNA-(apurinic or apyrimidinic site) endonuclease(Human)
University of Pittsburgh

US Patent
LigandPNGBDBM318446(NSC332395 | US9624235, Compound 4)
Affinity DataKi:  120nMAssay Description:The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetDNA-(apurinic or apyrimidinic site) endonuclease(Human)
University of Pittsburgh

US Patent
LigandPNGBDBM318446(NSC332395 | US9624235, Compound 4)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of recombinant His-6 tagged human APE1 expressed in Escherichia coli C41(DE3) using 5'-(F)-CGACTXTTGAATTGACACGCCATGTCGATCAATTCAATAGTCG-(D)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetDNA-(apurinic or apyrimidinic site) endonuclease(Human)
University of Pittsburgh

US Patent
LigandPNGBDBM318446(NSC332395 | US9624235, Compound 4)
Affinity DataIC50:  4.10E+3nMAssay Description:The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent