BDBM50156495 8-(dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-one::8-Dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one::8-dibenzothiophen-1-yl-2-morpholin-4-yl-chromen-4-one::CHEMBL188678::NU-7432::NU-7441
SMILES O=c1cc(oc2c(cccc12)-c1cccc2c3ccccc3sc12)N1CCOCC1
InChI Key InChIKey=JAMULYFATHSZJM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 28 hits for monomerid = 50156495
TargetDNA-dependent protein kinase catalytic subunit(Human)
School of Natural Sciences--Chemistry
Curated by ChEMBL
School of Natural Sciences--Chemistry
Curated by ChEMBL
Affinity DataKi: 0.650nMAssay Description:Inhibitory activity against DNA-dependent protein kinase receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of N-terminal 6His-tagged human BRDT bromodomain 1 (21 to 137 residues) expressed in Escherichia coli BL21 (DE3) using biotinylated histon...More data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Human)
School of Natural Sciences--Chemistry
Curated by ChEMBL
School of Natural Sciences--Chemistry
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibitory activity against DNA-dependent protein kinase (DNA-PK) at 0.5 uMMore data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Human)
School of Natural Sciences--Chemistry
Curated by ChEMBL
School of Natural Sciences--Chemistry
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against DNA-dependent protein kinase (DNA-PK)More data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Human)
School of Natural Sciences--Chemistry
Curated by ChEMBL
School of Natural Sciences--Chemistry
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of DNA-dependent protein kinaseMore data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Human)
School of Natural Sciences--Chemistry
Curated by ChEMBL
School of Natural Sciences--Chemistry
Curated by ChEMBL
TargetDNA-dependent protein kinase catalytic subunit(Human)
School of Natural Sciences--Chemistry
Curated by ChEMBL
School of Natural Sciences--Chemistry
Curated by ChEMBL
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human ERG expressed in cisapride treated CHO cells by Ion Works assayMore data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Human)
School of Natural Sciences--Chemistry
Curated by ChEMBL
School of Natural Sciences--Chemistry
Curated by ChEMBL
Affinity DataIC50: 42nMAssay Description:Inhibition of human DNA-PK using GST-tagged p53N66 as substrate after 1 hr by ELISA-based chemiluminiscence assayMore data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Human)
School of Natural Sciences--Chemistry
Curated by ChEMBL
School of Natural Sciences--Chemistry
Curated by ChEMBL
Affinity DataEC50: 212nMAssay Description:Inhibition of DNA-PK autophosphorylation at S2056 in human HeLa cellsMore data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Human)
School of Natural Sciences--Chemistry
Curated by ChEMBL
School of Natural Sciences--Chemistry
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of DNA-PK (unknown origin)More data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Human)
School of Natural Sciences--Chemistry
Curated by ChEMBL
School of Natural Sciences--Chemistry
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of DNA-PK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Ataxia telangiectasia related protein ATR kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of Mammalian target of Rapamycin mTORMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
University of Newcastle
Curated by ChEMBL
University of Newcastle
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of Phosphatidylinositol 3-kinase p110 alpha subunitMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Mutated in ataxia telangiectasia protein ATM kinaseMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
University of Newcastle
Curated by ChEMBL
University of Newcastle
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of PI3Kalpha after 80 minsMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 220nMAssay Description:Inhibition of PI-3K gamma (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
University of Newcastle
Curated by ChEMBL
University of Newcastle
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of PI-3K alpha (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of PI-3K delta (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of PI-3K beta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ATR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ATM (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Human)
School of Natural Sciences--Chemistry
Curated by ChEMBL
School of Natural Sciences--Chemistry
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of DNA-PK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of N-terminal 6His-tagged human BRD4 bromodomain 1 (44 to 168 residues) expressed in Escherichia coli BL21 (DE3) using biotinylated histon...More data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Human)
School of Natural Sciences--Chemistry
Curated by ChEMBL
School of Natural Sciences--Chemistry
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of DNA-dependent protein kinaseMore data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Human)
School of Natural Sciences--Chemistry
Curated by ChEMBL
School of Natural Sciences--Chemistry
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of DNA-PK autophosphorylation at Ser2056 residue in human CLL cells by Western blot methodMore data for this Ligand-Target Pair