BDBM50120433 ONO-5046.NA::Sivelestat Sodium

SMILES CC(C)(C)C(=O)Oc1ccc(cc1)S(=O)(=O)Nc1ccccc1C(=O)NCC([O-])=O

InChI Key InChIKey=BTGNGJJLZOIYID-UHFFFAOYSA-M

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50120433   

TargetNeutrophil elastase(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM50120433(ONO-5046.NA | Sivelestat Sodium)
Affinity DataIC50: 44nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM50120433(ONO-5046.NA | Sivelestat Sodium)
Affinity DataIC50: 50nMAssay Description:Inhibition of human neutrophil elastase using N-methylsuccinyl-Ala-Ala-Pro-Val-7-amino-4-methylcoumarin as substrate measured every 30 secs for 10 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM50120433(ONO-5046.NA | Sivelestat Sodium)
Affinity DataKi:  200nMAssay Description:Inhibition of human neutrophil elastase using suc-Ala-Pro-Ala-pNA as substrate after 30 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed