BDBM50120433 ONO-5046.NA::Sivelestat Sodium

SMILES CC(C)(C)C(=O)Oc1ccc(cc1)S(=O)(=O)Nc1ccccc1C(=O)NCC([O-])=O

InChI Key InChIKey=BTGNGJJLZOIYID-UHFFFAOYSA-M

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50120433   

TargetNeutrophil elastase(Human)
University of Florence

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50120433BDBM50120433(ONO-5046.NA | Sivelestat Sodium)
Affinity DataIC50: 44nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
University of Florence

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50120433BDBM50120433(ONO-5046.NA | Sivelestat Sodium)
Affinity DataIC50: 50nMAssay Description:Inhibition of human neutrophil elastase using N-methylsuccinyl-Ala-Ala-Pro-Val-7-amino-4-methylcoumarin as substrate measured every 30 secs for 10 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
University of Florence

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50120433BDBM50120433(ONO-5046.NA | Sivelestat Sodium)
Affinity DataKi:  200nMAssay Description:Inhibition of human neutrophil elastase using suc-Ala-Pro-Ala-pNA as substrate after 30 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetProlyl endopeptidase FAP(Human)
Charles University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50120433BDBM50120433(ONO-5046.NA | Sivelestat Sodium)
Affinity DataKi:  730nMAssay Description:Inhibition of recombinant human FAP extracted from S2 cells immobilized on plate surface using specific antibody assessed as inhibition constant meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed