BDBM50005677 CHEMBL23957::OXO-M::Trimethyl-[4-(2-oxo-pyrrolidin-1-yl)-but-2-ynyl]-ammonium; iodide

SMILES C[N+](C)(C)CC#CCN1CCCC1=O

InChI Key InChIKey=CANZROMYQDHYHR-UHFFFAOYSA-N

Data  10 KI  5 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50005677   

TargetMuscarinic acetylcholine receptor M2(Rat)
Medical Research Division of American Cyanamid

Curated by ChEMBL
LigandPNGBDBM50005677(CHEMBL23957 | OXO-M | Trimethyl-[4-(2-oxo-pyrrolid...)
Affinity DataKi:  0.780nMAssay Description:Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Human)
University of Arizona

Curated by PDSP Ki Database
LigandPNGBDBM50005677(CHEMBL23957 | OXO-M | Trimethyl-[4-(2-oxo-pyrrolid...)
Affinity DataKi:  2.5nMMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetMuscarinic acetylcholine receptor M2(Rat)
Medical Research Division of American Cyanamid

Curated by ChEMBL
LigandPNGBDBM50005677(CHEMBL23957 | OXO-M | Trimethyl-[4-(2-oxo-pyrrolid...)
Affinity DataKi:  60nMAssay Description:Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M2(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50005677(CHEMBL23957 | OXO-M | Trimethyl-[4-(2-oxo-pyrrolid...)
Affinity DataKi:  107nMAssay Description:Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M2(Rat)
Medical Research Division of American Cyanamid

Curated by ChEMBL
LigandPNGBDBM50005677(CHEMBL23957 | OXO-M | Trimethyl-[4-(2-oxo-pyrrolid...)
Affinity DataKi:  756nMMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetMuscarinic acetylcholine receptor M2(Rat)
Medical Research Division of American Cyanamid

Curated by ChEMBL
LigandPNGBDBM50005677(CHEMBL23957 | OXO-M | Trimethyl-[4-(2-oxo-pyrrolid...)
Affinity DataKi:  910nMAssay Description:Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Medical Research Division of American Cyanamid

Curated by ChEMBL
LigandPNGBDBM50005677(CHEMBL23957 | OXO-M | Trimethyl-[4-(2-oxo-pyrrolid...)
Affinity DataKi:  1.20E+3nMAssay Description:Binding affinity at [3H]PZ radiolabeled muscarinic M1 receptor in rat cortex.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M2(Rat)
Medical Research Division of American Cyanamid

Curated by ChEMBL
LigandPNGBDBM50005677(CHEMBL23957 | OXO-M | Trimethyl-[4-(2-oxo-pyrrolid...)
Affinity DataKi:  1.50E+3nMAssay Description:Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M3(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM50005677(CHEMBL23957 | OXO-M | Trimethyl-[4-(2-oxo-pyrrolid...)
Affinity DataKi:  8.70E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetMuscarinic acetylcholine receptor M1(Human)
University of Arizona

Curated by PDSP Ki Database
LigandPNGBDBM50005677(CHEMBL23957 | OXO-M | Trimethyl-[4-(2-oxo-pyrrolid...)
Affinity DataKi:  2.04E+4nMAssay Description:Binding affinity to human cloned muscarinic M1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005677(CHEMBL23957 | OXO-M | Trimethyl-[4-(2-oxo-pyrrolid...)
Affinity DataIC50:  2.30E+4nMAssay Description:Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]QNB as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005677(CHEMBL23957 | OXO-M | Trimethyl-[4-(2-oxo-pyrrolid...)
Affinity DataIC50:  13nMAssay Description:Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]OXO-M as radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005677(CHEMBL23957 | OXO-M | Trimethyl-[4-(2-oxo-pyrrolid...)
Affinity DataIC50:  13nMAssay Description:In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005677(CHEMBL23957 | OXO-M | Trimethyl-[4-(2-oxo-pyrrolid...)
Affinity DataIC50:  2.30E+4nMAssay Description:In vitro ability to displace [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005677(CHEMBL23957 | OXO-M | Trimethyl-[4-(2-oxo-pyrrolid...)
Affinity DataIC50:  1.20E+3nMAssay Description:Binding affinity to Muscarinic acetylcholine receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M3(Human)
University of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50005677(CHEMBL23957 | OXO-M | Trimethyl-[4-(2-oxo-pyrrolid...)
Affinity DataEC50:  1.80E+3nMAssay Description:Activation of M3-ACh receptor-FLASH/CFP expressed in HEK293 cells assessed as FRET signalMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Human)
University of Arizona

Curated by PDSP Ki Database
LigandPNGBDBM50005677(CHEMBL23957 | OXO-M | Trimethyl-[4-(2-oxo-pyrrolid...)
Affinity DataEC50:  7.40E+3nMAssay Description:Activation of M1-ACh receptor-FLASH/CFP expressed in HEK293 cells assessed as FRET signalMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Mouse)
The University of Toledo

Curated by ChEMBL
LigandPNGBDBM50005677(CHEMBL23957 | OXO-M | Trimethyl-[4-(2-oxo-pyrrolid...)
Affinity DataEC50:  700nMAssay Description:Tested against Muscarinic acetylcholine receptor M1 expressed in A9 L cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M5(Human)
University of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50005677(CHEMBL23957 | OXO-M | Trimethyl-[4-(2-oxo-pyrrolid...)
Affinity DataEC50:  2.30E+3nMAssay Description:Activation of M5-ACh receptor-FLASH/CFP expressed in HEK293 cells assessed as FRET signalMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed