BDBM50062614 CHEMBL900::Dimethyl-[2-(phenyl-o-tolyl-methoxy)-ethyl]-amine::Disipal::Invagesic::N,N-dimethyl-2-(phenyl(o-tolyl)methoxy)ethanamine::Norflex::Norgesic::ORPHENADRINE::Orphengesic

SMILES CN(C)CCOC(c1ccccc1)c1ccccc1C

InChI Key InChIKey=QVYRGXJJSLMXQH-UHFFFAOYSA-N

Data  10 KI  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50062614   

TargetMuscarinic acetylcholine receptor M1(Rat)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM50062614(CHEMBL900 | Dimethyl-[2-(phenyl-o-tolyl-methoxy)-e...)
Affinity DataKi:  40.7nMMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetMuscarinic acetylcholine receptor M1(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50062614(CHEMBL900 | Dimethyl-[2-(phenyl-o-tolyl-methoxy)-e...)
Affinity DataKi:  48nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor(Rabbit)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM50062614(CHEMBL900 | Dimethyl-[2-(phenyl-o-tolyl-methoxy)-e...)
Affinity DataKi:  81.3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetMuscarinic acetylcholine receptor M3(Rat)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM50062614(CHEMBL900 | Dimethyl-[2-(phenyl-o-tolyl-methoxy)-e...)
Affinity DataKi:  97.7nMMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetMuscarinic acetylcholine receptor M3(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50062614(CHEMBL900 | Dimethyl-[2-(phenyl-o-tolyl-methoxy)-e...)
Affinity DataKi:  120nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M5(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50062614(CHEMBL900 | Dimethyl-[2-(phenyl-o-tolyl-methoxy)-e...)
Affinity DataKi:  129nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M2(Rat)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM50062614(CHEMBL900 | Dimethyl-[2-(phenyl-o-tolyl-methoxy)-e...)
Affinity DataKi:  141nMMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetMuscarinic acetylcholine receptor M4(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50062614(CHEMBL900 | Dimethyl-[2-(phenyl-o-tolyl-methoxy)-e...)
Affinity DataKi:  170nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M2(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50062614(CHEMBL900 | Dimethyl-[2-(phenyl-o-tolyl-methoxy)-e...)
Affinity DataKi:  213nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M4(Chicken)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM50062614(CHEMBL900 | Dimethyl-[2-(phenyl-o-tolyl-methoxy)-e...)
Affinity DataKi:  214nMMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetCytochrome P450 1A2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062614(CHEMBL900 | Dimethyl-[2-(phenyl-o-tolyl-methoxy)-e...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50062614(CHEMBL900 | Dimethyl-[2-(phenyl-o-tolyl-methoxy)-e...)
Affinity DataIC50:  9.77E+4nMAssay Description:Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetHistamine H1 receptor(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50062614(CHEMBL900 | Dimethyl-[2-(phenyl-o-tolyl-methoxy)-e...)
Affinity DataIC50:  162nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50062614(CHEMBL900 | Dimethyl-[2-(phenyl-o-tolyl-methoxy)-e...)
Affinity DataIC50:  1.26E+4nMAssay Description:Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062614(CHEMBL900 | Dimethyl-[2-(phenyl-o-tolyl-methoxy)-e...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C9(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062614(CHEMBL900 | Dimethyl-[2-(phenyl-o-tolyl-methoxy)-e...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062614(CHEMBL900 | Dimethyl-[2-(phenyl-o-tolyl-methoxy)-e...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062614(CHEMBL900 | Dimethyl-[2-(phenyl-o-tolyl-methoxy)-e...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetCytochrome P450 2C19(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062614(CHEMBL900 | Dimethyl-[2-(phenyl-o-tolyl-methoxy)-e...)
Affinity DataIC50:  2.42E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tcg Lifesciences

Curated by ChEMBL
LigandPNGBDBM50062614(CHEMBL900 | Dimethyl-[2-(phenyl-o-tolyl-methoxy)-e...)
Affinity DataIC50:  851nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMultidrug and toxin extrusion protein 2(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50062614(CHEMBL900 | Dimethyl-[2-(phenyl-o-tolyl-methoxy)-e...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human MATE2-K expressed in HEK-293-Flp-In cells incubated for 3 mins by ASP+ substrate uptake assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMultidrug and toxin extrusion protein 1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50062614(CHEMBL900 | Dimethyl-[2-(phenyl-o-tolyl-methoxy)-e...)
Affinity DataIC50:  6.50E+4nMAssay Description:Inhibition of human MATE1 expressed in HEK-293-Flp-In cells incubated for 3 mins by ASP+ substrate uptake assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50062614(CHEMBL900 | Dimethyl-[2-(phenyl-o-tolyl-methoxy)-e...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 2(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50062614(CHEMBL900 | Dimethyl-[2-(phenyl-o-tolyl-methoxy)-e...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human OCT2 expressed in HEK-293-Flp-In cells incubated for 3 mins by ASP+ substrate uptake assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50062614(CHEMBL900 | Dimethyl-[2-(phenyl-o-tolyl-methoxy)-e...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human OCT1 expressed in HEK-293-Flp-In cells incubated for 3 mins by ASP+ substrate uptake assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed