BDBM50450813 Atripla::CHEBI:63625::GS-1275::PMP-A::Tenofovir::Truvada

SMILES C[C@H](Cn1cnc2c(N)ncnc12)OCP(O)(O)=O

InChI Key InChIKey=SGOIRFVFHAKUTI-ZCFIWIBFSA-N

Data  7 IC50  1 Kd  1 EC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50450813   

TargetCapsid protein(Hepatitis B virus)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM50450813(Atripla | CHEBI:63625 | GS-1275 | PMP-A | Tenofovi...)
Affinity DataEC50:  242nMAssay Description:Inhibition of hepatitis B virus capsid assembly infected in human HepG2.215 cells assessed as reduction in viral DNA replication measured on day 7 by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50450813(Atripla | CHEBI:63625 | GS-1275 | PMP-A | Tenofovi...)
Affinity DataIC50:  380nMAssay Description:Inhibition of HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50450813(Atripla | CHEBI:63625 | GS-1275 | PMP-A | Tenofovi...)
Affinity DataKd:  3.20E+3nMAssay Description:Binding affinity to ternary complex of HIV1 reverse transcriptase with primer/template in presence of dCTP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50450813(Atripla | CHEBI:63625 | GS-1275 | PMP-A | Tenofovi...)
Affinity DataIC50:  380nMAssay Description:Inhibition of wild type HIV 3B reverse transcriptase in MT2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50450813(Atripla | CHEBI:63625 | GS-1275 | PMP-A | Tenofovi...)
Affinity DataIC50:  4.58E+4nMAssay Description:Inhibition of human recombinant CYP3A4 expressed in insect microsome using 7-benzyloxy-4-trifluoromethylcoumarin as a substrate incubated for 30 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Michigan State University

LigandPNGBDBM50450813(Atripla | CHEBI:63625 | GS-1275 | PMP-A | Tenofovi...)
Affinity DataIC50:  1.42E+4nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Michigan State University

LigandPNGBDBM50450813(Atripla | CHEBI:63625 | GS-1275 | PMP-A | Tenofovi...)
Affinity DataIC50:  1.18E+4nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50450813(Atripla | CHEBI:63625 | GS-1275 | PMP-A | Tenofovi...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human recombinant CYP2D6 expressed in insect microsome using (3-[2-(N,N-dimethyl-N-methylammonium)-ethyl]-7-methoxy-4-methylcoumarin io...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50450813(Atripla | CHEBI:63625 | GS-1275 | PMP-A | Tenofovi...)
Affinity DataIC50:  380nMAssay Description:Inhibition on HIV1 reverse transcriptase p66/p51More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed