BDBM50582214 ATALUREN::Ataluren::PTC-124::PTC124::Translarna::US11744839, Compound of formula 4

SMILES OC(=O)c1cccc(c1)-c1noc(n1)-c1ccccc1F

InChI Key InChIKey=OOUGLTULBSNHNF-UHFFFAOYSA-N

Data  3 Kd  1 ITC

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50582214   

TargetFlavin reductase (NADPH)(Homo sapiens)
Korea Basic Science Institute

Curated by ChEMBL
LigandPNGBDBM50582214(ATALUREN | Ataluren | PTC-124 | PTC124 | Translarn...)
Affinity DataKd:  200nMAssay Description:Binding affinity to human N-terminal His6-tagged and thrombin cleavage fused BLVRB expressed in Escherichia coli BL21 (DE3) assessed as dissociation ...More data for this Ligand-Target Pair
TargetFlavin reductase (NADPH)(Homo sapiens)
Korea Basic Science Institute

Curated by ChEMBL
LigandPNGBDBM50582214(ATALUREN | Ataluren | PTC-124 | PTC124 | Translarn...)
Affinity DataKd:  200nMAssay Description:An enzyme activity assay for BLVRB was conducted. Since BLVRB catalyzes the NAD(P)H dependent readuction of FMN, changes in the NAD(P)H concentration...More data for this Ligand-Target Pair
TargetFlavin reductase (NADPH)(Homo sapiens)
Korea Basic Science Institute

Curated by ChEMBL
LigandPNGBDBM50582214(ATALUREN | Ataluren | PTC-124 | PTC124 | Translarn...)
Affinity DataKd:  200nMAssay Description:Binding affinity to human N-terminal His6-tagged and thrombin cleavage fused BLVRB expressed in Escherichia coli BL21 (DE3) assessed as dissociation ...More data for this Ligand-Target Pair

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 50582214   

CellFlavin reductase (NADPH)(Homo sapiens)
Korea Basic Science Institute

US Patent
SyringePNGBDBM50582214(ATALUREN | Ataluren | PTC-124 | PTC124 | Translarn...)
ITC DataΔG°: -9.12kcal/mole −TΔS°: 1.83kcal/mole ΔH°: -11.0kcal/mole logk: 4.93E+6
T: 25.00°C