BDBM50587736 CHEBI:8687::PYRVINIUM::Pyrvinium::Pyrvinium (cation)::Pyrvinium cation::Pyrvinium hydroxide::Pyrvinium ion::Pyrvinum (base)::US20240279201, Compound Pyrvinium

SMILES CN(C)c1ccc2[n+](C)c(\C=C\c3cc(C)n(c3C)-c3ccccc3)ccc2c1

InChI Key InChIKey=QMHSXPLYMTVAMK-UHFFFAOYSA-N

Data  6 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50587736   

TargetCasein kinase I isoform alpha(Human)
University of Connecticut

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50587736BDBM50587736(PYRVINIUM | CHEBI:8687 | Pyrvinium | Pyrvinium (ca...)
Affinity DataKd:  1nMAssay Description:Binding affinity to CK1alpha (unknown origin) using casein as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Henan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50587736BDBM50587736(PYRVINIUM | CHEBI:8687 | Pyrvinium | Pyrvinium (ca...)
Affinity DataIC50: 30nMAssay Description:Inhibition of PD-1/PD-L1 (unknown origin) protein-protein interaction incubated for 15 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50587736BDBM50587736(PYRVINIUM | CHEBI:8687 | Pyrvinium | Pyrvinium (ca...)
Affinity DataIC50: 190nMAssay Description:Antagonist activity at Androgen receptor in human LNCaP cells assessed as inhibition of DNA binding domain of AR measured by enhanced green fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCatenin beta-1/Protein Wnt-3a(Human)
University of Maryland at Baltimore

US Patent
LigandChemical structure of BindingDB Monomer ID 50587736BDBM50587736(PYRVINIUM | CHEBI:8687 | Pyrvinium | Pyrvinium (ca...)
Affinity DataIC50: 599nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetCatenin beta-1/Protein Wnt-3a(Human)
University of Maryland at Baltimore

US Patent
LigandChemical structure of BindingDB Monomer ID 50587736BDBM50587736(PYRVINIUM | CHEBI:8687 | Pyrvinium | Pyrvinium (ca...)
Affinity DataIC50: 599nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetCatenin beta-1/Protein Wnt-3a(Human)
University of Maryland at Baltimore

US Patent
LigandChemical structure of BindingDB Monomer ID 50587736BDBM50587736(PYRVINIUM | CHEBI:8687 | Pyrvinium | Pyrvinium (ca...)
Affinity DataIC50: 599nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50587736BDBM50587736(PYRVINIUM | CHEBI:8687 | Pyrvinium | Pyrvinium (ca...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of COT by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Henan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50587736BDBM50587736(PYRVINIUM | CHEBI:8687 | Pyrvinium | Pyrvinium (ca...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PD-1/PD-L1 interaction (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed