BDBM50557485 Prn-1008::Prn1008::Rilzabrutinib

SMILES CC(C)(\C=C(/C#N)C(=O)N1CCC[C@H](C1)n1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc12)N1CCN(CC1)C1COC1

InChI Key InChIKey=LCFFREMLXLZNHE-GBOLQPHISA-N

Data  7 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50557485   

TargetTyrosine-protein kinase BTK(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557485(Prn-1008 | Prn1008 | Rilzabrutinib)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of BTK (unknown origin) One-hour enzymatic assay without pre-incubationMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557485(Prn-1008 | Prn1008 | Rilzabrutinib)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of BTK (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557485(Prn-1008 | Prn1008 | Rilzabrutinib)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of BTK (unknown origin) using peptide substrate in presence of ATPMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Blk(Human)
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50557485(Prn-1008 | Prn1008 | Rilzabrutinib)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of BLK (unknown origin) using peptide substrate in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase Tec(Human)
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50557485(Prn-1008 | Prn1008 | Rilzabrutinib)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of TEC (unknown origin) using peptide substrate in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50557485(Prn-1008 | Prn1008 | Rilzabrutinib)
Affinity DataIC50:  1nMAssay Description:Inhibition of BMX (unknown origin) using peptide substrate in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase TXK(Human)
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50557485(Prn-1008 | Prn1008 | Rilzabrutinib)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of RLK (unknown origin) using peptide substrate in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails PubMed