BDBM50609506 DCC-2618::Dcc-2618::Qinlock::RIPRETINIB::Ripretinib
SMILES CCn1c2cc(NC)ncc2cc(-c2cc(NC(=O)Nc3ccccc3)c(F)cc2Br)c1=O
InChI Key InChIKey=CEFJVGZHQAGLHS-UHFFFAOYSA-N
Data 13 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 13 hits for monomerid = 50609506
TargetPlatelet-derived growth factor receptor alpha(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)
Curated by ChEMBL
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of wild type PDGFRA (unknown origin) extracted from Sf9 cells by HTRF assayMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)
Curated by ChEMBL
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Inhibition of PDGFRA D842V mutant (unknown origin) extracted from Sf9 cells by HTRF assayMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)
Curated by ChEMBL
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of wild type His-tagged KIT (unknown origin) extracted from Escherichia coli BL21 (DE3) by HTRF analysisMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)
Curated by ChEMBL
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of His-tagged KIT D816H mutant (unknown origin) extracted from Escherichia coli BL21 (DE3) by HTRF analysisMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)
Curated by ChEMBL
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)
Curated by ChEMBL
Affinity DataIC50: 9.20nMAssay Description:Inhibition of KIT T670I mutant (unknown origin)More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)
Curated by ChEMBL
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of wild type KIT (unknown origin)More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)
Curated by ChEMBL
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of KIT (delta560 to 576 residues) deletion mutant autophosphorylation at Y703 in human GIST430 harboring KIT (delta560 to 576 residues) de...More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)
Curated by ChEMBL
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of KIT V654A mutant (unknown origin) by FRET based assayMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)
Curated by ChEMBL
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)
Curated by ChEMBL
Affinity DataIC50: 185nMAssay Description:Inhibition of KIT (delta 560 to 576 residues) deletion/V654A double mutant autophosphorylation at Y703 in human GIST-430/654 harboring KIT (delta 560...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)
Curated by ChEMBL
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)
Curated by ChEMBL
Affinity DataIC50: 375nMAssay Description:Inhibition of N-terminal His10-tagged human PDGFRA T674I mutant (550 to 973 residues) extracted from Sf9 cells by HTRF assayMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)
Curated by ChEMBL
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)
Curated by ChEMBL
Affinity DataIC50: 642nMAssay Description:Inhibition of N-terminal His6-tagged human KIT T670I mutant (551 to 934 residues) extracted from Escherichia coli BL21 (DE3) by HTRF analysisMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)
Curated by ChEMBL
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of KIT D816V mutant (unknown origin)More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)
Curated by ChEMBL
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)
Curated by ChEMBL
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of PDGFRalpha D842V mutant (unknown origin)More data for this Ligand-Target Pair