BDBM50105327 JNJ-26481585::Quisinostat
SMILES Cn1cc(CNCC2CCN(CC2)c2ncc(cn2)C(=O)NO)c2ccccc12
InChI Key InChIKey=PAWIYAYFNXQGAP-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 99 hits for monomerid = 50105327
Affinity DataKi: 0.0300nMAssay Description:Inhibition of human HDAC1More data for this Ligand-Target Pair
Affinity DataKi: 0.0500nMAssay Description:Inhibition of human HDAC10More data for this Ligand-Target Pair
Affinity DataKi: 0.0600nMAssay Description:Inhibition of human HDAC2More data for this Ligand-Target Pair
Affinity DataKi: 0.0700nMAssay Description:Inhibition of human HDAC11More data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Inhibition of human HDAC4More data for this Ligand-Target Pair
Affinity DataKi: 0.480nMAssay Description:Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence methodMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibition of human HDAC8More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 1.70nMAssay Description:Inhibition of human recombinant HDAC7 using fluorogenic HDAC substrate class 2a after 45 mins by fluorimetrc methodMore data for this Ligand-Target Pair
Affinity DataKi: 2.10nMAssay Description:Inhibition of human HDAC5More data for this Ligand-Target Pair
Affinity DataKi: 2.10nMAssay Description:Inhibition of human HDAC3More data for this Ligand-Target Pair
Affinity DataKi: 3.80nMAssay Description:Inhibition of human HDAC9More data for this Ligand-Target Pair
Affinity DataKi: 4.30nMAssay Description:Inhibition of human recombinant HDAC5 using fluorogenic HDAC substrate class 2a after 30 mins by fluorimetrc methodMore data for this Ligand-Target Pair
Affinity DataKi: 4.30nMAssay Description:Inhibition of human recombinant HDAC3 using fluorogenic HDAC substrate after 10 mins by spectrophotometric methodMore data for this Ligand-Target Pair
Affinity DataKi: 4.40nMAssay Description:Inhibition of human recombinant HDAC10 using fluorogenic HDAC substrate after 45 mins by fluorimetrc methodMore data for this Ligand-Target Pair
Affinity DataKi: 5.30nMAssay Description:Inhibition of human recombinant HDAC9 using fluorogenic HDAC substrate class 2a after 30 mins by fluorimetrc methodMore data for this Ligand-Target Pair
Affinity DataKi: 6.70nMAssay Description:Inhibition of human recombinant HDAC4 using fluorogenic HDAC substrate class 2a after 30 mins by fluorimetrc methodMore data for this Ligand-Target Pair
Affinity DataKi: 7.30nMAssay Description:Inhibition of human recombinant HDAC1 using fluorogenic HDAC substrate after 15 mins by fluorimetrc methodMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Inhibition of human HDAC6More data for this Ligand-Target Pair
Affinity DataKi: 24nMAssay Description:Inhibition of human recombinant HDAC8 using fluorogenic HDAC substrate after 15 mins by fluorimetrc methodMore data for this Ligand-Target Pair
Affinity DataKi: 31nMAssay Description:Inhibition of human recombinant HDAC2 using fluorogenic HDAC substrate after 15 mins by fluorimetrc methodMore data for this Ligand-Target Pair
Affinity DataKi: 67nMAssay Description:Inhibition of human HDAC7More data for this Ligand-Target Pair
Affinity DataKi: 350nMAssay Description:Inhibition of human recombinant HDAC6 using fluorogenic HDAC substrate after 30 mins by fluorimetrc methodMore data for this Ligand-Target Pair
Affinity DataKi: 1.30E+3nMAssay Description:Inhibition of human recombinant HDAC11 using fluorogenic HDAC substrate class 2a after 30 mins by fluorimetrc methodMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
Nestle Skin Health R&D
Curated by ChEMBL
Nestle Skin Health R&D
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human recombinant SIRT3 using fluoro-lysine sirtuin 2 deacetylase substrate after 45 mins by fluorimetrc methodMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human recombinant SIRT2 using fluoro-lysine sirtuin 2 deacetylase substrate after 60 mins by fluorimetrc methodMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human recombinant SIRT1 using fluorogenic HDAC substrate after 20 mins by fluorimetrc methodMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of SIRT7 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.330nMAssay Description:Inhibition of full length recombinant human HDAC2 expressed in baculovirus infected Sf9 cells using RHKK-Ac as substrate by fluorescence analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.110nMAssay Description:Inhibition of full length recombinant human HDAC1 expressed in baculovirus infected Sf9 cells using RHKK-Ac as substrate by fluorescence analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 77nMAssay Description:Inhibition of full length recombinant human HDAC6 expressed in baculovirus infected Sf9 cells using RHKK-Ac as substrate by fluorescence analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
University of Navarra
Curated by ChEMBL
University of Navarra
Curated by ChEMBL
Affinity DataIC50: 4.90nMAssay Description:Inhibition of full length recombinant human HDAC3/NCOR2 expressed in baculovirus infected Sf9 cells using RHKK-Ac as substrate by fluorescence analys...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Human)
East China University of Science and Technology
Curated by ChEMBL
East China University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human LTA4H Epoxide Hydrolase expressed in Escherichia coli BL21 (DE3) pLysS preincubated for 10 mins followed by addition ...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Human)
East China University of Science and Technology
Curated by ChEMBL
East China University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human LTA4H aminopeptidase activity expressed in Escherichia coli BL21 (DE3) pLysS assessed as formation of p-NA from Ala-p...More data for this Ligand-Target Pair
Affinity DataIC50: 303nMAssay Description:Inhibition of Schistosoma mansoni His-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) cells using Fluor de Lys (R)-HDAC8 as substrate by fluoro...More data for this Ligand-Target Pair
Affinity DataIC50: 64nMAssay Description:Inhibition of human His-thioredoxin-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) cells using Fluor de Lys (R)-HDAC8 as substrate by fluorome...More data for this Ligand-Target Pair
Affinity DataIC50: 169nMAssay Description:Inhibition of human His-thioredoxin-tagged HDAC8 mL6/L179I mutant expressed in Escherichia coli BL21 (DE3) cells using Fluor de Lys (R)-HDAC8 as subs...More data for this Ligand-Target Pair
Affinity DataIC50: 217nMAssay Description:Inhibition of human His-thioredoxin-tagged HDAC8 mL1/mL6/L179I mutant expressed in Escherichia coli BL21 (DE3) cells using Fluor de Lys (R)-HDAC8 as ...More data for this Ligand-Target Pair
Affinity DataKd: 23nMAssay Description:Binding affinity to human His-thioredoxin-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) cells by ITC methodMore data for this Ligand-Target Pair
Affinity DataKd: 28nMAssay Description:Binding affinity to Schistosoma mansoni His-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) cells by ITC methodMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of dye-labeled tracer binding to HDAC10 (unknown origin) transfected in human HeLa cells measured after 2 hrs by nano-luciferase reporter ...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of tubastatin-Alexa647-tracer binding to recombinant GST-tagged HDAC10 (unknown origin) measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of recombinant full length human HDAC4 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 1.5 hrs ...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant full length human HDAC7 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 3 hrs by...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant full length human HDAC5 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 3 hrs by...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant full length human HDAC10 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Inhibition of recombinant full length human HDAC2 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.70nMAssay Description:Inhibition of recombinant human HDAC9 (604-1066 residues) expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.617nMAssay Description:Inhibition of recombinant full length human HDAC1 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.30nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4.30nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair