BDBM50074456 CHEMBL10504::SC241::[3-(2-Bromo-4-isopropyl-phenyl)-5-methyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]-bis-(2-methoxy-ethyl)-amine

SMILES COCCN(CCOC)c1nc(C)nc2n(nnc12)-c1ccc(cc1Br)C(C)C

InChI Key InChIKey=DMJNPPHUVMMIEQ-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50074456   

TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50074456(CHEMBL10504 | SC241 | [3-(2-Bromo-4-isopropyl-phen...)
Affinity DataKi:  3.70nMAssay Description:Compound was tested for the inhibition of binding of the radioligand, [125 I-Tyr0]-CRF to rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50074456(CHEMBL10504 | SC241 | [3-(2-Bromo-4-isopropyl-phen...)
Affinity DataKi:  3.70nMAssay Description:Antagonistic activity for Corticotropin releasing factor receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50074456(CHEMBL10504 | SC241 | [3-(2-Bromo-4-isopropyl-phen...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity to recombinant human Corticotropin releasing factor receptor 1 (hCRF1) expressed in 293EBNA cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Rattus norvegicus (rat))
Taisho Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50074456(CHEMBL10504 | SC241 | [3-(2-Bromo-4-isopropyl-phen...)
Affinity DataKi:  14.8nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCorticotropin-releasing factor receptor 1(Rattus norvegicus (rat))
Taisho Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50074456(CHEMBL10504 | SC241 | [3-(2-Bromo-4-isopropyl-phen...)
Affinity DataKi:  20.7nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCorticotropin-releasing factor receptor 2(RAT)
Taisho Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50074456(CHEMBL10504 | SC241 | [3-(2-Bromo-4-isopropyl-phen...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed