BDBM50297170 7-(2'-spiroindanyl)oxymorphone::7-(Spiroindano)Oxymorphone::7-spiroindanyloxymorphone::CHEMBL399708::SIOM::Spiroindanyloxymorphone

SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@]3(O)CC1(Cc2ccccc2C1)C4=O)ccc5O

InChI Key InChIKey=YJWDKWRVFJZBCJ-UHFFFAOYSA-N

Data  20 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50297170   

TargetDelta-type opioid receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50297170(Spiroindanyloxymorphone | 7-spiroindanyloxymorphon...)
Affinity DataKi:  1.40nMAssay Description:Selective binding affinity against Opioid receptor delta 1, using [3H]DPDPE as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50297170(Spiroindanyloxymorphone | 7-spiroindanyloxymorphon...)
Affinity DataKi:  2.80nMAssay Description:Inhibition of [3H]-NTI binding to Opioid receptor delta 1 from mouse brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50297170(Spiroindanyloxymorphone | 7-spiroindanyloxymorphon...)
Affinity DataKi:  2.80nMAssay Description:The compound tested for agonistic activity against Opioid receptor delta 1 using [3H]- NT1 as the radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50297170(Spiroindanyloxymorphone | 7-spiroindanyloxymorphon...)
Affinity DataKi:  3.30nMAssay Description:Selective binding affinity against Opioid receptor delta 2, using [3H]DSLET as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50297170(Spiroindanyloxymorphone | 7-spiroindanyloxymorphon...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [3H]- diprenorphine from mu-W318A-receptor expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50297170(Spiroindanyloxymorphone | 7-spiroindanyloxymorphon...)
Affinity DataKi:  4.10nMAssay Description:Displacement of [3H]- diprenorphine from delta receptor expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50297170(Spiroindanyloxymorphone | 7-spiroindanyloxymorphon...)
Affinity DataKi:  10.6nMAssay Description:Displacement of [3H]DAMGO from Hartley guinea pig mu opioid receptor by liquid scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50297170(Spiroindanyloxymorphone | 7-spiroindanyloxymorphon...)
Affinity DataKi:  11nMAssay Description:selective binding affinity against mu opioid receptor, using [3H]DAMGO as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Mouse)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50297170(Spiroindanyloxymorphone | 7-spiroindanyloxymorphon...)
Affinity DataKi:  14nMAssay Description:Inhibition of [3H]DAMGO binding to Opioid receptor mu 1 from mouse brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50297170(Spiroindanyloxymorphone | 7-spiroindanyloxymorphon...)
Affinity DataKi:  14nMAssay Description:The compound tested for agonistic activity against Opioid receptor mu 1 using [3H]- DAMGO as the radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50297170(Spiroindanyloxymorphone | 7-spiroindanyloxymorphon...)
Affinity DataKi:  46.6nMAssay Description:Displacement of [3H]- diprenorphine from delta-W284E-receptor expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50297170(Spiroindanyloxymorphone | 7-spiroindanyloxymorphon...)
Affinity DataKi:  55nMAssay Description:Displacement of [3H]diprenorphine from k-Y312A-receptor expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50297170(Spiroindanyloxymorphone | 7-spiroindanyloxymorphon...)
Affinity DataKi:  88.4nMAssay Description:Displacement of [3H]- diprenorphine from mu-receptor expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50297170(Spiroindanyloxymorphone | 7-spiroindanyloxymorphon...)
Affinity DataKi:  154nMAssay Description:Displacement of [3H]- diprenorphine from mu-K303E-receptor expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50297170(Spiroindanyloxymorphone | 7-spiroindanyloxymorphon...)
Affinity DataKi:  292nMAssay Description:Displacement of [3H]diprenorphine from k-E297A-receptor expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50297170(Spiroindanyloxymorphone | 7-spiroindanyloxymorphon...)
Affinity DataKi:  488nMAssay Description:Displacement of [3H]diprenorphine from opioid receptor kappa 1 expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50297170(Spiroindanyloxymorphone | 7-spiroindanyloxymorphon...)
Affinity DataKi:  588nMAssay Description:Displacement of [3H]U69493 from Hartley guinea pig kappa opioid receptor by liquid scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50297170(Spiroindanyloxymorphone | 7-spiroindanyloxymorphon...)
Affinity DataKi:  588nMAssay Description:selective binding affinity against kappa opioid receptor, using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Mouse)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50297170(Spiroindanyloxymorphone | 7-spiroindanyloxymorphon...)
Affinity DataKi: >3.00E+3nMAssay Description:Inhibition of [3H]U-69593 binding to Opioid receptor kappa 1 from mouse brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50297170(Spiroindanyloxymorphone | 7-spiroindanyloxymorphon...)
Affinity DataKi: >3.00E+3nMAssay Description:The compound tested for agonistic activity against Opioid receptor kappa 1 as the [3H]- U-69,594 radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMed