BDBM50341636 (3Z)-N-(3-CHLOROPHENYL)-3-({3,5-DIMETHYL-4-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-1H-PYRROL-2-YL}METHYLENE)-N-METHYL-2-OXOINDOLINE-5-SULFONAMIDE::(3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide::(3Z)-N-(3-chlorophenyl)-3-({3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl}methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide::CHEMBL261641::N-(3-chlorophenyl)-3-((3,5-dimethyl-4-(1-methylpiperazine-4-carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxoindoline-5-sulfonamide::N-(3-chlorophenyl)-3-((3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxoindoline-5-sulfonamide::SU-11274

SMILES CN(c1cccc(Cl)c1)S(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c(C)c(C(=O)N4CCN(C)CC4)c3C)c2c1

InChI Key InChIKey=FPYJSJDOHRDAMT-KQWNVCNZSA-N

Data  2 KI  9 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50341636   

TargetProtein-tyrosine kinase 2-beta(Human)
Sandia National Laboratories

Curated by ChEMBL
LigandPNGBDBM50341636((3Z)-N-(3-CHLOROPHENYL)-3-({3,5-DIMETHYL-4-[(4-MET...)
Affinity DataKi:  10.5nMAssay Description:Inhibition of human recombinant PYK2 by ESI-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase ZAP-70(Human)
Sandia National Laboratories

Curated by ChEMBL
LigandPNGBDBM50341636((3Z)-N-(3-CHLOROPHENYL)-3-({3,5-DIMETHYL-4-[(4-MET...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human recombinant ZAP70 using EEEEYEEEE as substrate by ESI-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50341636((3Z)-N-(3-CHLOROPHENYL)-3-({3,5-DIMETHYL-4-[(4-MET...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50341636((3Z)-N-(3-CHLOROPHENYL)-3-({3,5-DIMETHYL-4-[(4-MET...)
Affinity DataIC50:  152nMAssay Description:Inhibition of Met-mediated scattering in HGF-stimulated human MDCK cells pre-incubated overnight prior to HGF stimulation for 24 hrs measured after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50341636((3Z)-N-(3-CHLOROPHENYL)-3-({3,5-DIMETHYL-4-[(4-MET...)
Affinity DataIC50:  1.56E+3nMAssay Description:Inhibition of Met-mediated tumorigenesis in HGF-stimulated human HepG2 cells assessed as impairment in anchorage-independent growth by soft agar grow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50341636((3Z)-N-(3-CHLOROPHENYL)-3-({3,5-DIMETHYL-4-[(4-MET...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human GST tagged c-Met CD expressed in Sf9 cells using poly(Glu:Tyr) as substrate incubated for 5 mins in presence of ATP by horseradis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50341636((3Z)-N-(3-CHLOROPHENYL)-3-({3,5-DIMETHYL-4-[(4-MET...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Met kinaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Dog)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50341636((3Z)-N-(3-CHLOROPHENYL)-3-({3,5-DIMETHYL-4-[(4-MET...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Met-triggered cell scattering in HGF-stimulated MDCK cells preincubated for overnight before HGF challenge measured after 24 to 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50341636((3Z)-N-(3-CHLOROPHENYL)-3-({3,5-DIMETHYL-4-[(4-MET...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant c-MET kinase in A549 cells assessed as inhibition of HGF-induced cell growthMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50341636((3Z)-N-(3-CHLOROPHENYL)-3-({3,5-DIMETHYL-4-[(4-MET...)
Affinity DataIC50:  14nMAssay Description:Inhibition of purified recombinant c-Met after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50341636((3Z)-N-(3-CHLOROPHENYL)-3-({3,5-DIMETHYL-4-[(4-MET...)
Affinity DataIC50:  228nMAssay Description:Inhibition of Met-mediated tumorigenesis in HGF-stimulated human GTL16 cells assessed as impairment in anchorage-independent growth by soft agar grow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed