BDBM50111603 3-(4-(dimethylamino)benzylidene)indolin-2-one::3-(4-Dimethylamino-benzylidene)-1,3-dihydro-indol-2-one::3-[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one::CHEMBL296455::SU-4312::US11111252, Compound DMBI::US9422297, DMBI

SMILES CN(C)c1ccc(\C=C2\C(=O)Nc3ccccc23)cc1

InChI Key InChIKey=UAKWLVYMKBWHMX-UHFFFAOYSA-N

Data  6 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50111603   

LigandPNGBDBM50111603(3-(4-(dimethylamino)benzylidene)indolin-2-one | 3-...)
Affinity DataIC50: 794nMAssay Description:Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Duquesne University of The Holy Spirit

US Patent
LigandPNGBDBM50111603(3-(4-(dimethylamino)benzylidene)indolin-2-one | 3-...)
Affinity DataIC50: 3.75E+3nMAssay Description:Table 9: Compounds 1 and 2, Section D., (see FIG. 4, bottom row, far right column) each inhibit VEGFR-2 and PDGFR-β for antiangiogenic effects a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2022
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Duquesne University of The Holy Spirit

US Patent
LigandPNGBDBM50111603(3-(4-(dimethylamino)benzylidene)indolin-2-one | 3-...)
Affinity DataIC50: 3.75E+3nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
US Patent

TargetBeta-lactamase(Escherichia coli (strain K12))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50111603(3-(4-(dimethylamino)benzylidene)indolin-2-one | 3-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory activity against beta-lactamaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetEphrin type-B receptor 2(Human)
Protana

Curated by ChEMBL
LigandPNGBDBM50111603(3-(4-(dimethylamino)benzylidene)indolin-2-one | 3-...)
Affinity DataKd:  1.95E+4nMAssay Description:Equilibrium binding constant for EPH receptor B2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEphrin type-B receptor 2(Human)
Protana

Curated by ChEMBL
LigandPNGBDBM50111603(3-(4-(dimethylamino)benzylidene)indolin-2-one | 3-...)
Affinity DataIC50: 2.75E+4nMAssay Description:Inhibition of EPH receptor B2 using ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymotrypsin-C(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50111603(3-(4-(dimethylamino)benzylidene)indolin-2-one | 3-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibitory activity against chymotrypsinogenMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed