BDBM50373697 Sapropterin::TETRAHYDROBIOPTERIN

SMILES C[C@@H]([C@@H]([C@H]1CNC2=C(N1)C(=O)NC(=N2)N)O)O

InChI Key InChIKey=FNKQXYHWGSIFBK-UHFFFAOYSA-N

Data  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50373697   

TargetNitric oxide synthase, brain(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50373697(Sapropterin | TETRAHYDROBIOPTERIN | US12257253, Co...)
Affinity DataKd:  1.12E+3nMAssay Description:Activity of tetrahydrobiopterin free nNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetPhenylalanine-4-hydroxylase(Human)
Som Innovation Biotech

US Patent
LigandPNGBDBM50373697(Sapropterin | TETRAHYDROBIOPTERIN | US12257253, Co...)
Affinity DataKd:  4.07E+4nMAssay Description:ITC experiments were performed at 25° C. using a MicroCal PEAQ-ITC microcalorimeter (Malvern). PAH proteins were prepared in a HEPES buffer (HEPES 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2025
Entry Details
US Patent