BDBM50155929 CHEMBL225157::TAK-242

SMILES CCOC(=O)C1=CCCC[C@H]1S(=O)(=O)Nc1ccc(F)cc1Cl

InChI Key InChIKey=LEEIJTHMHDMWLJ-CQSZACIVSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50155929   

TargetToll-like receptor 4(Homo sapiens (Human))
Soochow University

Curated by ChEMBL
LigandPNGBDBM50155929(CHEMBL225157 | TAK-242)
Affinity DataIC50:  680nMAssay Description:Inhibition of human TLR4 signaling expressed in HEK-Blue cells co-expressing MD2/CD14 assessed as reduction in LPS-induced NF-kappaB activation-media...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50155929(CHEMBL225157 | TAK-242)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of TLR4 in LPS/INFgamma stimulated mouse peritoneal macrophages assessed as inhibition of IL1-beta after 20 hrs by ELISA analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed