BDBM50050533 6-BENZYL-1-BENZYLOXYMETHYL-5-ISOPROPYL URACIL::6-Benzyl-1-benzyloxymethyl-5-isopropyl-1H-pyrimidine-2,4-dione::6-benzyl-1-(benzyloxymethyl)-5-isopropyluracil::CHEMBL436546::TNK-651

SMILES CC(C)c1c(Cc2ccccc2)n(COCc2ccccc2)c(=O)[nH]c1=O

InChI Key InChIKey=KSAAUHMSLCPIEX-UHFFFAOYSA-N

Data  6 IC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50050533   

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Oxford University

Curated by ChEMBL
LigandPNGBDBM50050533(6-BENZYL-1-BENZYLOXYMETHYL-5-ISOPROPYL URACIL | 6-...)
Affinity DataIC50:  6nMAssay Description:Inhibitory activity of the compound against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetIntegrase(Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50050533(6-BENZYL-1-BENZYLOXYMETHYL-5-ISOPROPYL URACIL | 6-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HIV1 integrase expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase(Human immunodeficiency virus type 1)
Peking University

Curated by ChEMBL
LigandPNGBDBM50050533(6-BENZYL-1-BENZYLOXYMETHYL-5-ISOPROPYL URACIL | 6-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of HIV1 reverse transcriptase using poly(ra)/oligo(dT)15 homopolymer template as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetReverse transcriptase(Human immunodeficiency virus type 1)
Peking University

Curated by ChEMBL
LigandPNGBDBM50050533(6-BENZYL-1-BENZYLOXYMETHYL-5-ISOPROPYL URACIL | 6-...)
Affinity DataIC50:  40nMAssay Description:Inhibition of HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetReverse transcriptase(Human immunodeficiency virus type 1)
Peking University

Curated by ChEMBL
LigandPNGBDBM50050533(6-BENZYL-1-BENZYLOXYMETHYL-5-ISOPROPYL URACIL | 6-...)
Affinity DataIC50:  88nMAssay Description:Inhibition of HIV1 reverse transcriptase after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetReverse transcriptase(Human immunodeficiency virus type 1)
Peking University

Curated by ChEMBL
LigandPNGBDBM50050533(6-BENZYL-1-BENZYLOXYMETHYL-5-ISOPROPYL URACIL | 6-...)
Affinity DataIC50:  16nMAssay Description:Inhibition of HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)