BDBM50019167 CHEMBL3289109

SMILES Cc1ccc(cc1)-c1nc2ccccc2c(=O)[nH]1

InChI Key InChIKey=UTEHUKGJDLVHIH-UHFFFAOYSA-N

Data  3 KI  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50019167   

TargetAdenosine receptor A1(Rat)
North-West University

Curated by ChEMBL
LigandPNGBDBM50019167(CHEMBL3289109)
Affinity DataKi:  2.50E+3nMAssay Description:Displacement of [3H]DPCPX from Sprague-Dawley rat whole brain membrane A1AR by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Rat)
North-West University

Curated by ChEMBL
LigandPNGBDBM50019167(CHEMBL3289109)
Affinity DataKi:  2.95E+3nMAssay Description:Displacement of [3H]DPCPX from Sprague-Dawley rat whole brain membrane A1AR in presence of GTP by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A2a(Rat)
North-West University

Curated by ChEMBL
LigandPNGBDBM50019167(CHEMBL3289109)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]NECA from Sprague-Dawley rat striatal membrane A2A adenosine receptor by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50019167(CHEMBL3289109)
Affinity DataIC50:  346nMAssay Description:Inhibition of TNKS-1 (unknown origin) using histone as substrate incubated for 30 mins by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50019167(CHEMBL3289109)
Affinity DataIC50:  540nMAssay Description:Inhibition of N-terminal GST-tagged human TNKS-2 (849 to 1166 residues) expressed in in insect sf21 cells preincubated for 2 hrs followed by substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetBeta-glucuronidase(Human)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50019167(CHEMBL3289109)
Affinity DataIC50:  1.73E+5nMAssay Description:Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50019167(CHEMBL3289109)
Affinity DataIC50:  424nMAssay Description:Inhibition of PARP-1 (unknown origin) using histone as substrate incubated for 1 hr by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed