BDBM50424716 NOSCAPINE::Narcotine::Tusscapine

SMILES COc1ccc2[C@H](OC(=O)c2c1OC)[C@@H]1N(C)CCc2cc3OCOc3c(OC)c12

InChI Key InChIKey=AKNNEGZIBPJZJG-MSOLQXFVSA-N

Data  4 IC50  1 Kd

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50424716   

TargetSimilar to alpha-tubulin isoform 1(Bovine)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50424716(NOSCAPINE | Narcotine | Tusscapine)
Affinity DataIC50: >4.00E+5nMAssay Description:Inhibition of bovine brain tubulin assessed as extent of assembly preincubated for 15 mins by turbidimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSimilar to alpha-tubulin isoform 1(Bovine)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50424716(NOSCAPINE | Narcotine | Tusscapine)
Affinity DataIC50:  1.70E+5nMAssay Description:Inhibition of bovine brain tubulin assessed as rate of assembly preincubated for 15 mins by turbidimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTubulin beta-3 chain(Human)
Shahid Beheshti University

Curated by ChEMBL
LigandPNGBDBM50424716(NOSCAPINE | Narcotine | Tusscapine)
Affinity DataKd:  579nMAssay Description:Binding affinity to CM5 chip immobilized beta tubulin (unknown origin) assessed as thermodynamic constants by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50424716(NOSCAPINE | Narcotine | Tusscapine)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMultidrug and toxin extrusion protein 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50424716(NOSCAPINE | Narcotine | Tusscapine)
Affinity DataIC50:  3.45E+4nMAssay Description:Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed